Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Prince Sattam Chair for Epidemiology and Public Health Research, Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Front Immunol. 2023 Jul 17;14:1206636. doi: 10.3389/fimmu.2023.1206636. eCollection 2023.
Asthma affects a significant number of individuals in Saudi Arabia, with increasing prevalence worldwide, leading to a considerable impact on their quality of life and frequent hospitalizations. In this study, we aimed to explore the relationship between the immune cell ratio and coagulation markers, specifically to identify the occurrence of coagulation abnormalities associated with asthma. To achieve this, we assessed asthma history and severity using a questionnaire while analyzing coagulation biomarkers through venous blood samples. The biomarkers examined included d-dimer, prothrombin time (PT), partial thromboplastin time (PTT), and the international normalized ratio (INR). In addition, we evaluated various hematological parameters such as blood cell counts and hemoglobin (HGB) levels. Our findings revealed compelling evidence, showing significantly elevated levels of d-dimer and the eosinophil-to-neutrophil (ENR) ratio in asthma cases compared to the controls. Moreover, we observed a positive correlation between d-dimer levels and the ENR, with each unit increase in d-dimer associated with a 0.0006 increase in the ENR among asthma cases. These results highlight the potential of assessing ENR and d-dimer levels as predictive indicators for disease prognosis and the development of coagulation abnormalities in individuals with asthma. By shedding light on the relationship between immune cell ratios and coagulation markers in the context of asthma, our study contributes to a better understanding of disease progression and the associated complications. These insights can potentially lead to improved management strategies and better outcomes for asthma patients.
哮喘在沙特阿拉伯影响着大量人群，其在全球范围内的患病率不断增加，对患者的生活质量产生了重大影响，并导致其频繁住院。在这项研究中，我们旨在探讨免疫细胞比值与凝血标志物之间的关系，特别是确定与哮喘相关的凝血异常的发生情况。为此，我们通过问卷调查评估哮喘病史和严重程度，并通过静脉血样分析凝血生物标志物。检查的生物标志物包括 D-二聚体、凝血酶原时间（PT）、部分凝血活酶时间（PTT）和国际标准化比值（INR）。此外，我们还评估了各种血液学参数，如血细胞计数和血红蛋白（HGB）水平。我们的研究结果表明，与对照组相比，哮喘患者的 D-二聚体和嗜酸性粒细胞与中性粒细胞（ENR）比值显著升高，这一发现令人信服。此外，我们观察到 D-二聚体水平与 ENR 之间呈正相关，在哮喘患者中，D-二聚体每增加一个单位，ENR 就会增加 0.0006。这些结果强调了评估 ENR 和 D-二聚体水平作为疾病预后和哮喘患者凝血异常发展的预测指标的潜力。通过阐明哮喘背景下免疫细胞比值与凝血标志物之间的关系，我们的研究有助于更好地理解疾病进展和相关并发症。这些见解可能为哮喘患者的管理策略和更好的结果提供指导。
