坦度螺酮致重度抑郁症伴焦虑痛苦患者便血一例报告
Hematochezia caused by tandospirone in a patient with major depressive disorder and anxious distress: a case report.
作者信息
Jiang Xingmei, Ma Zhongrui, Li Zhixiong, Ou Ying, Luo Zhenhua, Li Zhe
机构信息
Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Sichuan Clinical Medical Research Center for Mental Disorders, Chengdu, Sichuan, China.
出版信息
Front Psychiatry. 2023 Jul 17;14:1209354. doi: 10.3389/fpsyt.2023.1209354. eCollection 2023.
BACKGROUND
Major depressive disorder (MDD) with anxious distress is a relatively common condition that is often associated with a poor treatment response. In order to enhance the effectiveness of MDD treatment, 5-HT1A agonists like tandospirone are often prescribed in conjunction with antidepressants. While it is known that antidepressants can increase the risk of bleeding, whether tandospirone poses a similar risk remains uncertain.
CASE PRESENTATION
We presented the case of a 55-year-old Chinese woman diagnosed with MDD and anxious distress. After receiving various types of antidepressants, she experienced hematochezia following the administration of tandospirone, sertraline, and agomelatine. The occurrence of hematochezia ceased after tandospirone was discontinued. The patient was subsequently discharged with a treatment regime consisting of sertraline and agomelatine. During the 1-month follow-up, she reported no hematochezia.
CONCLUSION
Tandospirone may potentially increase the risk of hematochezia in patients with MDD and anxious distress.
背景
伴有焦虑性痛苦的重度抑郁症（MDD）是一种相对常见的病症，常与治疗反应不佳相关。为提高MDD的治疗效果，通常会将坦度螺酮等5-HT1A激动剂与抗抑郁药联合使用。虽然已知抗抑郁药会增加出血风险，但坦度螺酮是否有类似风险仍不确定。
病例报告
我们报告了一名55岁中国女性的病例，该患者被诊断为MDD并伴有焦虑性痛苦。在接受了多种抗抑郁药治疗后，她在服用坦度螺酮、舍曲林和阿戈美拉汀后出现了便血。停用坦度螺酮后，便血情况停止。患者随后出院，治疗方案为服用舍曲林和阿戈美拉汀。在1个月的随访中，她报告没有便血。
结论
坦度螺酮可能会增加患有MDD和焦虑性痛苦患者的便血风险。
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