Fogel Matisyahu S, Koide Kazunori
Department of Chemistry, University of Pittsburgh 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, United States.
Org Process Res Dev. 2023 Jul 11;27(7):1235-1247. doi: 10.1021/acs.oprd.3c00128. eCollection 2023 Jul 21.
Traditionally, new synthetic reactions have been developed using a model substrate to screen reaction conditions before testing the optimized conditions with a range of more complex substrates. In 1998, Gao and Kagan pooled multiple substrates in one pot to study the generality of an enantioselective method. Although such one-pot multisubstrate screenings may be powerful, few applications have appeared in the literature. With the advancement of various chromatography techniques, it may be time to revisit this underutilized platform. This review article discusses the applications of one-pot multisubstrate screenings as a method for developing new synthetic methods.
传统上，新的合成反应是通过使用模型底物来筛选反应条件，然后再用一系列更复杂的底物测试优化后的条件来开发的。1998年，高和卡根将多种底物混合在一个反应釜中，以研究对映选择性方法的通用性。尽管这种一锅多底物筛选可能很有效，但文献中出现的应用却很少。随着各种色谱技术的进步，也许是时候重新审视这个未得到充分利用的平台了。这篇综述文章讨论了一锅多底物筛选作为开发新合成方法的一种手段的应用。
