Lan Xiao-Hua, Hu Yue, Cao Yan-Jie, Liu Ping, Ren Qi-Tao, Zhu Wei-Wei
Air Force Medical Center, PLA Beijing China.
Graduate School of Hebei North University Zhangjiakou Hebei Province China.
Clin Case Rep. 2023 Jul 30;11(8):e7713. doi: 10.1002/ccr3.7713. eCollection 2023 Aug.
Linezolid (LZD) is an efficient addition antibiotic against multidrug-resistant strains. However, clinicians should pay attention to the adverse reactions such as hypoglycemia and anemia in using LZD, especially in elderly patients and patients with abnormal liver and kidney function who need to use LZD for a long time.
Severe hypoglycemia and anemia caused by linezolid (LZD) are rare, with potentially serious adverse effects. The report of LZD-induced hypoglycemia and anemia is extremely rare. Thus far, this is the first report. We presented LZD-induced recurrent hypoglycemia and anemia in a 93-year-old patient who has been prescribed LZD 600 mg once daily for 42 days for treatment of tuberculosis (TB) pleurisy and pneumonia. The patient began to experience recurrent hypoglycemic episodes and anemia 5 days and 2 weeks after LZD medication, respectively. Using Naranjo's Adverse Drug Reaction Assessment Scale, the patient scored 8 points with the category of "probable". His hypoglycemia and anemia gradually improved 1 month after LZD withdrawal. Clinicians should pay attention to the adverse reactions such as hypoglycemia and anemia in using LZD, especially in elderly patients and patients with abnormal liver and kidney function who need to use LZD for a long time. Patients should regularly monitor blood routine, blood glucose, and liver and kidney functions during LZD exposure, which may avoid adverse reactions and improve their prognosis.
利奈唑胺（LZD）是一种针对多重耐药菌株的有效附加抗生素。然而，临床医生在使用LZD时应注意低血糖和贫血等不良反应，尤其是在老年患者以及需要长期使用LZD的肝肾功能异常患者中。
利奈唑胺（LZD）引起的严重低血糖和贫血较为罕见，但可能产生严重不良反应。关于LZD诱发低血糖和贫血的报道极为罕见。迄今为止，这是首例报告。我们报告了一名93岁患者，因治疗结核性胸膜炎和肺炎，每日一次服用600mg LZD，共42天，出现了LZD诱发的反复低血糖和贫血。患者分别在服用LZD后5天和2周开始出现反复低血糖发作和贫血。使用Naranjo药物不良反应评估量表，患者评分为8分，属于“很可能”类别。停用LZD 1个月后，他的低血糖和贫血逐渐改善。临床医生在使用LZD时应注意低血糖和贫血等不良反应，尤其是在老年患者以及需要长期使用LZD的肝肾功能异常患者中。在LZD治疗期间，患者应定期监测血常规、血糖以及肝肾功能，这可能避免不良反应并改善预后。
