Johannesmeyer Herman Joseph, Bhakta Suhani, Morales Felix
Pharmacy Practice, College of Pharmacy, Marshall B. Ketchum University, Fullerton, USA.
Family Medicine, School of Medicine, Texas Tech University Health Sciences Center, 3601 4th Street Stop 8143, Lubbock, TX, 79430-8143, USA.
Drug Saf Case Rep. 2017 Nov 9;4(1):18. doi: 10.1007/s40800-017-0061-0.
Our case describes a 77-year-old, African American male who was experiencing recurrent hypoglycemic episodes, which resulted in two emergency department (ED) visits and a subsequent inpatient admission during his second ED visit. He was prescribed linezolid 600 mg twice daily for 14 days for the treatment of a Staphylococcus hominis urinary tract infection. Nine and a half days into therapy, the patient began having recurrent hypoglycemic episodes. These episodes persisted despite repeated intravenous dextrose boluses. The patient's linezolid was discontinued during the second day of his inpatient admission. After a brief lag period after the final linezolid administration, the patient's blood glucose level stabilized within normal limits. He was later discharged home. The Naranjo scale scores the causality of this reaction between 4 and 8, indicating possible to probable causality. The patient had a follow-up appointment with his primary care physician 2 weeks after discharge, with no noted blood glucose complications. Two months after discharge, he entered hospice care for his advancing heart failure and later expired due to causes unrelated to blood glucose complications.
我们的病例描述了一位77岁的非裔美国男性，他反复出现低血糖发作，导致两次前往急诊科就诊，并在第二次就诊后住院。他因感染人葡萄球菌尿路感染，接受了为期14天、每天两次、每次600毫克利奈唑胺的治疗。治疗九天半后，患者开始反复出现低血糖发作。尽管多次静脉注射葡萄糖推注，这些发作仍持续存在。患者住院第二天停用了利奈唑胺。在最后一次使用利奈唑胺后的短暂延迟期后，患者的血糖水平稳定在正常范围内。他后来出院回家。Naranjo量表对该反应的因果关系评分为4至8分，表明可能至很可能存在因果关系。患者出院两周后与他的初级保健医生进行了随访，未发现血糖并发症。出院两个月后，他因进行性心力衰竭进入临终关怀护理，后来因与血糖并发症无关的原因去世。
