Fuhrman B, Brook J G, Aviram M
Ann Nutr Metab. 1986;30(4):250-60. doi: 10.1159/000177201.
The influence of 2 different fatty meals, rich in either saturated or polyunsaturated fatty acids, on platelet aggregation in 7 normolipemic subjects and in 10 patients with phenotype IV hyperlipemia, was studied. 3 h after ingestion of a saturated- or polyunsaturated-fat-rich meal, plasma triglycerides were similarly increased in both groups. 5 h after ingestion of fat of either origin, the plasma triglyceride level in normal subjects returned almost to the fasting level, whereas in patients with hypertriglyceridemia it was still elevated. Platelet aggregation induced by ADP in platelet-rich plasma significantly increased in the normal group 3 h after both meals, whereas in the patient group it increased only after the saturated-fat-rich meal. These results were not changed 5 h after the meals. Postprandial elevated platelet activity was not correlated with increased plasma triglyceride concentration. No changes were found in washed-platelet aggregation in normal subjects, whereas the patient-derived washed platelets showed increased aggregation after the saturated-fat-rich meal. Plasma chylomicrons prepared from both groups during alimentary hyperlipemia inhibited ADP-induced platelet aggregation as well as thrombin-induced platelet 14C-serotonin release. This study indicates that the intake of fatty meals induces acute disturbance in platelet aggregation, favoring thrombosis. These changes are more comprehensive in hyperlipemic patients and after a saturated-fat-rich meal.
研究了富含饱和脂肪酸或多不饱和脂肪酸的两种不同脂肪餐对7名血脂正常受试者和10名IV型高脂血症患者血小板聚集的影响。摄入富含饱和脂肪或多不饱和脂肪的餐食3小时后，两组的血浆甘油三酯均有类似升高。摄入任何一种来源的脂肪5小时后，正常受试者的血浆甘油三酯水平几乎恢复到空腹水平，而高甘油三酯血症患者的血浆甘油三酯水平仍升高。富含血小板血浆中由ADP诱导的血小板聚集在正常组进食后3小时显著增加，而在患者组中仅在摄入富含饱和脂肪的餐食后增加。餐后5小时这些结果未改变。餐后血小板活性升高与血浆甘油三酯浓度升高无关。正常受试者的洗涤血小板聚集未发现变化，而患者来源的洗涤血小板在摄入富含饱和脂肪的餐食后聚集增加。两组在饮食性高脂血症期间制备的血浆乳糜微粒均抑制ADP诱导的血小板聚集以及凝血酶诱导的血小板14C-5-羟色胺释放。本研究表明，摄入脂肪餐会引起血小板聚集的急性紊乱，有利于血栓形成。这些变化在高脂血症患者中更全面，且在摄入富含饱和脂肪的餐食后更明显。
