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麻风病的罕见表现：两例报告

Uncommon Presentation of Leprosy: A Report of Two Cases.

作者信息

Supekar Bhagyashree B, Soni Rajesh, Bhushan Ravi, Mukhi Jayesh I, Singh Rajesh P, Bhat Dharitri

机构信息

From the Department of Dermatology, Venereology and Leprology, Government Medical College and Hospital, Nagpur, Maharashtra, India.

Department of Pathology, Government Medical College and Hospital, Nagpur, Maharashtra, India.

出版信息

Indian J Dermatol. 2023 May-Jun;68(3):313-317. doi: 10.4103/ijd.IJD_671_20.

DOI:10.4103/ijd.IJD_671_20
PMID:37529443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10389125/
Abstract

Lazarine leprosy is an unusual expression of usually borderline tuberculoid (BT) form characterized by spontaneous ulceration of skin lesions. This is presumably the result of an exaggerated type 1 reaction. It commonly occurs in the BT, borderline lepromatous forms and rarely in the lepromatous forms of leprosy. We report two cases of lazarine leprosy in the BT and BT downgrading to borderline lepromatous spectrum in healthy and immunocompetent males.

摘要

拉扎里尼麻风是通常为界线类偏结核型（BT）麻风的一种特殊表现形式，其特征为皮肤损害出现自发性溃疡。这可能是1型反应过度的结果。它常见于BT型、界线类偏瘤型麻风，而在瘤型麻风中罕见。我们报告了两例发生在健康且免疫功能正常男性身上的BT型拉扎里尼麻风病例，以及BT型向界线类偏瘤型转变的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/4541a6582842/IJD-68-313-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/132e1c7bb2bd/IJD-68-313-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/9ed1b13032e7/IJD-68-313-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/1f040e5fd10f/IJD-68-313-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/6ff8042c350e/IJD-68-313-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/e03773b44aef/IJD-68-313-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/bb0ee61e4691/IJD-68-313-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/85605749673b/IJD-68-313-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/145a731b8ac3/IJD-68-313-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/2203fcf4db38/IJD-68-313-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/4541a6582842/IJD-68-313-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/132e1c7bb2bd/IJD-68-313-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/9ed1b13032e7/IJD-68-313-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/1f040e5fd10f/IJD-68-313-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/6ff8042c350e/IJD-68-313-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/e03773b44aef/IJD-68-313-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/bb0ee61e4691/IJD-68-313-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/85605749673b/IJD-68-313-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/145a731b8ac3/IJD-68-313-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/2203fcf4db38/IJD-68-313-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9c/10389125/4541a6582842/IJD-68-313-g010.jpg

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本文引用的文献

1
Ulcerating type 1 lepra reaction mimicking lazarine leprosy: an unusual presentation of immune reconstitution inflammatory syndrome in an HIV-infected patient.模仿拉扎里尼麻风的1型溃疡型麻风反应：一名HIV感染患者免疫重建炎症综合征的不寻常表现。
Int J STD AIDS. 2013 Dec;24(12):992-4. doi: 10.1177/0956462413490144. Epub 2013 Aug 28.
2
New insights in the pathogenesis of type 1 and type 2 lepra reaction.1 型和 2 型麻风反应发病机制的新见解。
Indian J Dermatol Venereol Leprol. 2013 Nov-Dec;79(6):739-49. doi: 10.4103/0378-6323.120719.
3
Vasculonecrotic reactions in leprosy.
麻风病中的血管坏死反应。
Braz J Infect Dis. 2007 Jun;11(3):378-82. doi: 10.1590/s1413-86702007000300016.
4
Lazarine leprosy--revisited?拉扎林麻风病——重新审视？
Indian J Lepr. 2004 Oct-Dec;76(4):351-4.
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Lazarine leprosy--revisited.拉扎林麻风病——再探讨。
Indian J Lepr. 2005 Apr-Jun;77(2):182-3; author reply 183.
6
The role of protein malnutrition in the pathogenesis of ulcerative "Lazarine" leprosy.蛋白质营养不良在溃疡性“拉扎林”麻风病发病机制中的作用。
Int J Lepr Other Mycobact Dis. 1976 Jul-Sep;44(3):346-58.
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[Lepromatous leprosy with extensive ulcerations and cachexia. The Lucio phenomenon? Lazarine leprosy?].[瘤型麻风伴广泛溃疡和恶病质。卢西奥现象？拉扎林麻风？]
Acta Leprol. 1979 Sep-Dec(76-77):331-3.