Babu C S, Kannan K B, Bharadwaj V P, Katoch V M
Central JALMA Institute for Leprosy, Agra.
Indian J Med Res. 1990 May;91:193-6.
Arginase activity was estimated in serum and lymphocytes of 22 healthy controls and 50 untreated leprosy patients across the spectrum. The patients included 21 lepromatous/borderline lepromatous (LL/BL); 20 borderline borderline/borderline tuberculoid (BB/BT) and 9 tuberculoid (TT) cases. Mean serum arginase levels were 1.51 +/- 0.43, 1.41 +/- 0.43, 1.24 +/- 0.43 and 1.10 +/- 0.026 mu moles/min/ml in LL/BL, BB/BT and TT patients and healthy controls respectively. The lymphocyte arginase activity showed a similar increasing trend from TT to LL/BL. The mean lymphocyte arginase levels were 0.87 +/- 0.31 mu moles/min/10(6) cells in healthy controls and 1.81 +/- 0.40, 2.54 +/- 0.60 and 5.48 +/- 0.56 mu moles/min/10(6) cells in TT, BB/BT and LL/BL patients respectively. The increasing trend specially in lymphocyte arginase levels across the spectrum of leprosy correlated with the degree of impairment in the protective cell mediated immune response and also the extent of disease. The role of these pathophysiological alterations in relation to defect in immune response calls for investigation.
在22名健康对照者和50名未经治疗的各型麻风病患者的血清和淋巴细胞中评估了精氨酸酶活性。患者包括21例瘤型/界线类偏瘤型（LL/BL）；20例界线类偏界线类/界线类偏结核样型（BB/BT）和9例结核样型（TT）病例。LL/BL、BB/BT和TT患者以及健康对照者的血清精氨酸酶平均水平分别为1.51±0.43、1.41±0.43、1.24±0.43和1.10±0.026微摩尔/分钟/毫升。淋巴细胞精氨酸酶活性从TT到LL/BL呈现出类似的上升趋势。健康对照者的淋巴细胞精氨酸酶平均水平为0.87±0.31微摩尔/分钟/10⁶个细胞，TT、BB/BT和LL/BL患者的该水平分别为1.81±0.40、2.54±0.60和5.48±0.56微摩尔/分钟/10⁶个细胞。特别是麻风病各型中淋巴细胞精氨酸酶水平的上升趋势与保护性细胞介导免疫反应的受损程度以及疾病的范围相关。这些病理生理改变在免疫反应缺陷方面的作用需要进行研究。
