肾脏侵袭试验：其在Lewis肺癌系统中的应用。
The kidney invasion test: its application to the Lewis lung carcinoma system.
作者信息
Van Ginckel R, Vanherck W, Willebrords R, Distelmans W, De Brabander M
出版信息
Anticancer Res. 1986 Jul-Aug;6(4):705-8.
PMID:3752948
Abstract
Implantation of fragments from subcutaneously grown Lewis lung carcinoma 3LL under the renal capsule of syngeneic mice results in invasion of the kidney parenchyma. The synthetic microtubule inhibitor tubulozole blocks or decreases this malignant invasion in a dose-dependent manner. The inhibition of the invasion rate caused by tubulozole can be macroscopically quantified, and has been confirmed histologically.
摘要
将皮下生长的同基因小鼠Lewis肺癌3LL的片段植入同基因小鼠的肾被膜下，会导致肾实质受到侵袭。合成微管抑制剂tubulozole以剂量依赖的方式阻断或减少这种恶性侵袭。由tubulozole引起的侵袭率抑制可通过宏观定量，并且已得到组织学证实。
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