Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Department of Human and Medical Genetics, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Front Endocrinol (Lausanne). 2023 Jul 17;14:1186014. doi: 10.3389/fendo.2023.1186014. eCollection 2023.
Poor sleep quality is associated with different physical and mental health diseases. It is proposed that increased hypothalamic-pituitary-adrenal axis activity is a potential contributor affecting sleep pattern and quality. We aimed to analyze the relationship between subjective sleep quality indicators and hair glucocorticoid levels among relatively healthy perimenopausal and postmenopausal women.
A total of 145 women aged 50-64 y.o. were enrolled in the cross-sectional pilot study. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index, while stress level was measured using the Perceived Stress Scale. Hair cortisol and cortisone levels were determined by ultra-high-performance liquid chromatography-tandem mass spectrometry.
Statistically significant positive relationship was found between hair cortisol concentration and Pittsburgh sleep quality index score. Similarly, statistically significant positive associations were observed between hair total glucocorticoid level and Pittsburgh sleep quality index, sleep disturbance, and Perceived Stress Scale scores. Subjects with prolonged sleep latency had significantly higher hair cortisol and total hair glucocorticoid concentrations compared with individuals whose sleep latency is not disturbed. Additionally, Chi-squared test indicated that lower hair cortisol concentration was significantly related to better sleep efficiency.
Increased hair glucocorticoid (cortisol, cortisone) levels were found to be related with worse sleep quality measured by Pittsburgh sleep quality index score.
睡眠质量差与各种身心健康疾病有关。据推测，下丘脑-垂体-肾上腺轴活性增加是影响睡眠模式和质量的潜在因素。我们旨在分析相对健康的围绝经期和绝经后妇女的主观睡眠质量指标与头发皮质醇水平之间的关系。
共纳入 145 名年龄在 50-64 岁的女性进行横断面试点研究。使用匹兹堡睡眠质量指数评估睡眠质量，使用感知压力量表测量压力水平。通过超高效液相色谱-串联质谱法测定头发皮质醇和皮质酮水平。
头发皮质醇浓度与匹兹堡睡眠质量指数评分呈显著正相关。同样，头发总皮质醇水平与匹兹堡睡眠质量指数、睡眠障碍和感知压力量表评分之间也存在显著正相关。与睡眠潜伏期不受干扰的个体相比，睡眠潜伏期延长的受试者的头发皮质醇和总头发生长皮质醇浓度显著更高。此外，卡方检验表明，较低的头发皮质醇浓度与更好的睡眠效率显著相关。
头发皮质醇（皮质醇、皮质酮）水平升高与匹兹堡睡眠质量指数评分所示的睡眠质量较差有关。
