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Purastat作为急性食管静脉曲张出血的辅助治疗选择：一例报告

Purastat as an Adjunct Treatment Option in Acute Esophageal Varices Bleeding: A Case Report.

作者信息

Hassan Imran H, Elphick David, Al-Rifaie Ammar

机构信息

Gastroenterology, Chesterfield Royal Hospital, Chesterfield, GBR.

出版信息

Cureus. 2023 Jul 30;15(7):e42712. doi: 10.7759/cureus.42712. eCollection 2023 Jul.

DOI:10.7759/cureus.42712
PMID:37529804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10387821/
Abstract

Esophageal varices are dilated submucosal esophageal veins that connect the portal and systemic circulations. Bleeding esophageal varices is a well-recognized complication of liver cirrhosis.It is known that in active variceal bleeding, treatment needs to be started promptly. Treatments comprise band ligation, sclerotherapy, removable stent placement, balloon tamponade, and transjugular intrahepatic portosystemic shunt (TIPS).We report a case in which hemodynamic stability can be maintained with the use of Purastat to control bleeding.

摘要

食管静脉曲张是连接门静脉和体循环的扩张的食管黏膜下静脉。食管静脉曲张破裂出血是肝硬化一种公认的并发症。众所周知，在活动性静脉曲张出血时，需要立即开始治疗。治疗方法包括套扎术、硬化疗法、可移除支架置入、气囊压迫和经颈静脉肝内门体分流术（TIPS）。我们报告了一例使用Purastat控制出血从而维持血流动力学稳定的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c9/10387821/db3d3d5ff9d0/cureus-0015-00000042712-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c9/10387821/938dec9cef65/cureus-0015-00000042712-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c9/10387821/3983de4356d6/cureus-0015-00000042712-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c9/10387821/60ef2c782040/cureus-0015-00000042712-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c9/10387821/db3d3d5ff9d0/cureus-0015-00000042712-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c9/10387821/938dec9cef65/cureus-0015-00000042712-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c9/10387821/3983de4356d6/cureus-0015-00000042712-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c9/10387821/60ef2c782040/cureus-0015-00000042712-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c9/10387821/db3d3d5ff9d0/cureus-0015-00000042712-i04.jpg

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本文引用的文献

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A case of gastric antral vascular ectasia in which PuraStat, a novel self-assembling peptide hemostatic hydrogel, was effective.一例胃窦血管扩张症，新型自组装肽止血水凝胶PuraStat对其有效。
DEN Open. 2022 Nov 10;3(1):e183. doi: 10.1002/deo2.183. eCollection 2023 Apr.
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The role of a novel self-expanding metal stent in variceal bleeding: a multicenter Australian and New Zealand experience.一种新型自膨式金属支架在静脉曲张出血中的作用：澳大利亚和新西兰多中心经验
Endosc Int Open. 2022 Mar 14;10(3):E238-E245. doi: 10.1055/a-1729-0104. eCollection 2022 Mar.
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Endoscopically delivered Purastat for the treatment of severe haemorrhagic radiation proctopathy: a service evaluation of a new endoscopic treatment for a challenging condition.
内镜下应用Purastat治疗严重出血性放射性直肠炎：对一种具有挑战性疾病的新型内镜治疗的服务评估
Frontline Gastroenterol. 2021 Jan 19;12(7):608-613. doi: 10.1136/flgastro-2020-101735. eCollection 2021.
4
PuraStat in gastrointestinal bleeding: results of a prospective multicentre observational pilot study.普拉斯塔特在胃肠道出血中的应用：一项前瞻性多中心观察性试点研究结果。
Surg Endosc. 2022 May;36(5):2954-2961. doi: 10.1007/s00464-021-08589-6. Epub 2021 Jun 15.
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A novel fully synthetic and self-assembled peptide solution for endoscopic submucosal dissection-induced ulcer in the stomach.一种用于治疗胃内镜黏膜下剥离术后溃疡的新型全合成自组装肽溶液。
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Self-Expandable Metal Stents for Persisting Esophageal Variceal Bleeding after Band Ligation or Injection-Therapy: A Retrospective Study.用于套扎或注射治疗后持续性食管静脉曲张出血的自膨式金属支架：一项回顾性研究
PLoS One. 2015 Jun 22;10(6):e0126525. doi: 10.1371/journal.pone.0126525. eCollection 2015.
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Management of acute variceal bleeding.急性静脉曲张出血的管理
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Pediatr Gastroenterol Hepatol Nutr. 2013 Dec;16(4):248-53. doi: 10.5223/pghn.2013.16.4.248. Epub 2013 Dec 31.
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