Spitzbarth Benjamin, Eelkema Rienk
Department of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Chem Commun (Camb). 2023 Sep 19;59(75):11174-11187. doi: 10.1039/d3cc02126b.
Over the last few decades, the study of more complex, chemical systems closer to those found in nature, and the interactions within those systems, has grown immensely. Despite great efforts, the need for new, versatile, and robust chemistry to apply in CRNs remains. In this Feature Article, we give a brief overview over previous developments in the field of systems chemistry and how β'-substituted Michael acceptors (MAs) can be a great addition to the systems chemist's toolbox. We illustrate their versatility by showcasing a range of examples of applying β'-substituted MAs in CRNs, both as chemical signals and as substrates, to open up the path to many applications ranging from responsive materials, to pathway control in CRNs, drug delivery, analyte detection, and beyond.
在过去几十年里，对更复杂的、更接近自然界中发现的化学系统及其内部相互作用的研究有了巨大的发展。尽管付出了巨大努力，但在化学反应网络（CRNs）中应用新型、通用且稳健的化学方法的需求仍然存在。在这篇专题文章中，我们简要概述了系统化学领域以前的发展情况，以及β'-取代的迈克尔受体（MAs）如何能成为系统化学家工具箱中的一项重要补充。我们通过展示一系列在CRNs中应用β'-取代的MAs作为化学信号和底物的例子，来说明它们的多功能性，从而为从响应材料到CRNs中的途径控制、药物递送、分析物检测等众多应用开辟道路。
