Merck & Co., Inc., Rahway, NJ, USA.
SunFire Biotechnologies LLC, Birmingham, AL, USA.
Hum Vaccin Immunother. 2023 Aug 1;19(2):2235238. doi: 10.1080/21645515.2023.2235238.
Pneumococcal serogroups consist of structurally related serotypes, and serotype-specific antibodies can cross-react against other serotypes within the same serogroup. Cross-reactivity of vaccine-induced serotype 6A antibodies, and, to a lesser extent, serotype 6B antibodies, to serotype 6C has been demonstrated following receipt of the 13-valent pneumococcal conjugate vaccine (PCV13), which contains serotypes 6A and 6B. V114 is a 15-valent PCV containing the 13 PCV13 serotypes plus two additional serotypes, 22F and 33F. This study assessed cross-reactivity to serotype 6C in recipients of V114 and PCV13 as well as specificity of opsonophagocytic activity (OPA) responses in serogroup 6. Following receipt of V114 or PCV13, the observed OPA geometric mean titers to serotypes 6A, 6B, and 6C were comparable across both vaccination groups (post-single dose in adults ≥50 years of age [ = 250] and from pre- to post-dose 4 in pediatric participants 12-15 months of age [ = 150]). Based on OPA inhibition studies, V114 induced cross-reactive antibodies to serotype 6C in adult and pediatric populations that were specific and comparable to those induced by PCV13. Based on experience with PCV13, V114 may also provide comparable protection against pneumococcal disease caused by serotype 6C; however, this will have to be evaluated in real-world studies.
肺炎球菌血清群由结构相关的血清型组成，针对同一血清群内其他血清型的特异性抗体可发生交叉反应。在接种 13 价肺炎球菌结合疫苗（PCV13）后，已证明疫苗诱导的 6A 型抗体，以及在较小程度上的 6B 型抗体，对 6C 型血清型具有交叉反应性，PCV13 含有 6A 和 6B 型血清型。V114 是一种 15 价 PCV，包含 13 种 PCV13 血清型加另外两种血清型 22F 和 33F。这项研究评估了 V114 和 PCV13 接种者对血清型 6C 的交叉反应性以及 6 血清群中调理吞噬活性（OPA）反应的特异性。在接种 V114 或 PCV13 后，在两个接种组中，观察到的针对血清型 6A、6B 和 6C 的 OPA 几何平均滴度相当（在 50 岁及以上成人单次剂量后[ = 250]和儿科参与者 12-15 个月时从预剂量到第 4 剂量[ = 150]）。基于 OPA 抑制研究，V114 在成人和儿科人群中诱导了针对血清型 6C 的交叉反应性抗体，这些抗体具有特异性且与 PCV13 诱导的抗体相当。根据 PCV13 的经验，V114 也可能对由血清型 6C 引起的肺炎球菌病提供类似的保护；然而，这将需要在真实世界的研究中进行评估。
