和在埃及急性淋巴细胞白血病患者中的预后价值：一项单中心研究。（你提供的原文中“the and ”表述不完整，请补充完整准确内容以便能更精准翻译）

The prognostic values of the and in Egyptian patients with acute lymphoblastic leukemia: A single-center study.

作者信息

El Baiomy Mohamed A, Akl Tamer, ElMenshawy Nadia, El-Sebaie Ahmed H, Morkos Hanna, El-Ashwah Shaimaa, El-Sabbagh Amr M, Wahba Yahya, El-Ghonemy Mohamed

机构信息

Department of Internal Medicine, Medical Oncology Unit, Mansoura University Oncology Center, Mansoura, Egypt.

Clinical Pathology Department, Hematology Unit, Mansoura University, Mansoura, Egypt.

出版信息

Indian J Cancer. 2023 Apr-Jun;60(2):217-223. doi: 10.4103/ijc.IJC_102_21.

DOI:10.4103/ijc.IJC_102_21

PMID:37530244

Abstract

BACKGROUND

Interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-α) genes contribute to oncogenesis. We evaluated the influence of the IL-10 (G1082A) and TNF-α (G308A) polymorphisms on the prognosis and outcomes of Egyptian patients with acute lymphoblastic leukemia (ALL).

MATERIALS AND METHODS

We investigated 64 children and 76 adults with ALL, between 2016 and 2019, for the IL-10 (G1082A) and TNF-α (G308A) polymorphisms using allele-specific polymerase chain reaction and polymerase chain reaction-restriction fragment length polymorphism. Survival analyses were performed using the Kaplan-Meier estimator and the log-rank test.

RESULTS

In children with ALL, the A allele of TNF-α and IL-10 polymorphisms was associated with older age (P = 0.04 and 0.03), more extramedullary disease (P = 0.02 and 0.001), positive breakpoint cluster region-Abelson (BCR-ABL) rearrangement (p190; P = 0.04 and 0.001), and more relapse (P = 0.002). The IL-10 GG genotype was associated with higher overall survival in children (P = 0.026). Adults carrying the TNF-α A allele showed more extramedullary disease (P = 0.009) and relapse (P = 0.003). We also found a higher frequency of IL-10 A allele in adults with older age (P = 0.03), lower hemoglobin level (P = 0.04), positive BCR-ABL rearrangement (P = 0.001), more extramedullary disease (P = 0.001), more relapse (P = 0.002), and a longer time for the first complete remission (P = 0.003).

CONCLUSION

A possible association exists between the A allele of IL-10 and TNF-α polymorphisms and poor prognosis in Egyptian patients with ALL, while the IL-10 GG genotype may be associated with better survival in children with ALL.

摘要

背景

白细胞介素-10（IL-10）和肿瘤坏死因子-α（TNF-α）基因参与肿瘤发生。我们评估了IL-10（G1082A）和TNF-α（G308A）基因多态性对埃及急性淋巴细胞白血病（ALL）患者预后和结局的影响。

材料与方法

在2016年至2019年期间，我们使用等位基因特异性聚合酶链反应和聚合酶链反应-限制性片段长度多态性方法，对64名儿童和76名成人ALL患者进行了IL-10（G1082A）和TNF-α（G308A）基因多态性检测。使用Kaplan-Meier估计器和对数秩检验进行生存分析。

结果

在儿童ALL患者中，TNF-α和IL-10基因多态性的A等位基因与年龄较大（P = 0.04和0.03）、更多髓外疾病（P = 0.02和0.001）、阳性断裂点簇区域-阿贝尔森（BCR-ABL）重排（p190；P = 0.04和0.001）以及更多复发（P = 0.002）相关。IL-10 GG基因型与儿童较高的总生存率相关（P = 0.026）。携带TNF-α A等位基因的成人表现出更多髓外疾病（P = 0.009）和复发（P =

0.003）。我们还发现，年龄较大的成人ALL患者中IL-10 A等位基因频率较高（P = 0.03），血红蛋白水平较低（P = 0.04），BCR-ABL重排阳性（P = 0.001），髓外疾病更多（P = 0.001），复发更多（P = 0.002），首次完全缓解时间更长（P = 0.003）。