Chin Yu-Ting, Tsai Chung-Lin, Ma Hung-Huan, Cheng Da-Chuan, Tsai Chia-Wen, Wang Yun-Chi, Shih Hou-Yu, Chang Shu-Yu, Gu Jian, Chang Wen-Shin, Bau Da-Tian
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung 404327, Taiwan.
Life (Basel). 2024 Aug 20;14(8):1035. doi: 10.3390/life14081035.
Prostate cancer (PCa) is a multifactorial disease influenced by genetic, environmental, and immunological factors. Genetic polymorphisms in the () gene have been implicated in PCa susceptibility, development, and progression. This study aims to assess the contributions of three promoter single nucleotide polymorphisms (SNPs), A-1082G (rs1800896), T-819C (rs3021097), and A-592C (rs1800872), to the risk of PCa in Taiwan. The three genotypes were determined using PCR-RFLP methodology and were evaluated for their contributions to PCa risk among 218 PCa patients and 436 non-PCa controls. None of the three SNPs were significantly associated with the risks of PCa ( all > 0.05) in the overall analyses. However, the GG at rs1800896 combined with smoking behavior was found to significantly increase the risk of PCa by 3.90-fold (95% confidence interval [95% CI] = 1.28-11.89, = 0.0231). In addition, the rs1800896 AG and GGs were found to be correlated with the late stages of PCa (odds ratio [OR] = 1.90 and 6.42, 95% CI = 1.05-3.45 and 2.30-17.89, = 0.0452 and 0.0003, respectively). The promoter SNP, A-1082G (rs1800896), might be a risk factor for PCa development among smokers and those at late stages of the disease. These findings should be validated in larger and more diverse populations.
前列腺癌（PCa）是一种受遗传、环境和免疫因素影响的多因素疾病。（）基因中的遗传多态性与PCa易感性、发展和进展有关。本研究旨在评估三个启动子单核苷酸多态性（SNP），即A-1082G（rs1800896）、T-819C（rs3021097）和A-592C（rs1800872）对台湾地区PCa风险的影响。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法确定这三种基因型，并在218例PCa患者和436例非PCa对照中评估它们对PCa风险的影响。在总体分析中，这三个SNP均与PCa风险无显著关联（所有P值均>0.05）。然而，发现rs1800896位点的GG基因型与吸烟行为相结合会使PCa风险显著增加3.90倍（95%置信区间[95%CI]=1.28-11.89，P=0.0231）。此外，发现rs1800896的AG和GG基因型与PCa晚期相关（优势比[OR]=1.90和6.42，95%CI=1.05-3.45和2.30-17.89，P分别为0.0452和0.0003）。启动子SNP A-1082G（rs1800896）可能是吸烟者和疾病晚期患者PCa发生的危险因素。这些发现应在更大且更多样化的人群中进行验证。
