Esmer Murat, Schingale Franz Josef
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Gazi University, Ankara, Turkey.
Lympho Opt Clinic, Pommelsbrunn-Hohenstadt, Germany.
Lymphat Res Biol. 2023 Oct;21(5):501-503. doi: 10.1089/lrb.2023.0007. Epub 2023 Aug 2.
The presence of edema in patients with lipedema has been investigated in many studies. However, no study has been found that examines the amount of intracellular (ICF) and extracellular fluid (ECF) in these patients together. The aim of this study is to examine the amount of ICF and ECF in patients with stage 2 lipedema. Twenty-four patients diagnosed with stage 2 lipedema were included in the study. Bioimpedance spectroscopy was applied to measure extracellular and intracellular water levels. The mean age of the participants was 44.58 ± 2.95 years. The mean body mass index (BMI) of the participants was 33.9 ± 1.84 kg/m. It was observed that the amount of ECF in the patients was above the normal values ( < 0.001), whereas the amount of ICF was within the normal range ( = 0.801). In addition, it was observed that there was a moderate relationship between BMI and the amount of ECF. Although the amount of ICF is within the normal range in patients with lipedema, an increase in ECF is observed. The reason why edema is not observed in these patients despite the increase in ECF may be the increase in glycosaminoglycan and proteoglycan synthesis. In addition, the attention of these patients to weight control may contribute to slowing the course of the disease by preventing the increase in the amount of ECF. For a better diagnosis of lipedema, it is considered important to evaluate the amount of ECF in addition to routine evaluations.
许多研究都对脂肪性水肿患者的水肿情况进行了调查。然而，尚未发现有研究同时检测这些患者的细胞内液（ICF）和细胞外液（ECF）量。本研究的目的是检测2期脂肪性水肿患者的ICF和ECF量。24例被诊断为2期脂肪性水肿的患者纳入本研究。应用生物电阻抗光谱法测量细胞外和细胞内的水分含量。参与者的平均年龄为44.58±2.95岁。参与者的平均体重指数（BMI）为33.9±1.84kg/m²。观察到患者的ECF量高于正常值（<0.001），而ICF量在正常范围内（=0.801）。此外，观察到BMI与ECF量之间存在中度相关性。尽管脂肪性水肿患者的ICF量在正常范围内，但ECF量有所增加。这些患者尽管ECF增加但未观察到水肿的原因可能是糖胺聚糖和蛋白聚糖合成增加。此外，这些患者对体重控制的关注可能有助于通过防止ECF量增加来减缓疾病进程。为了更好地诊断脂肪性水肿，除了常规评估外，评估ECF量也被认为很重要。
