Li Juanjuan, Wu Yu, Chen Cheng, Zhang Wanfen, Yue Lili, Liu Tongqiang
Division of Nephrology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, 68 Gehu Road, Hutang Town, Wujin District, Changzhou, Jiangsu, China.
Clin Exp Nephrol. 2024 Jan;28(1):1-12. doi: 10.1007/s10157-023-02386-2. Epub 2023 Aug 2.
Nephrotoxicity remains the most serious side effect of cisplatin therapy. Cisplatin-induced nephrotoxicity (CIN) limits the use of this drug and affects up to 20% of patients. Several possible interventions such as magnesium supplementation may prevent CIN. This study aimed to review different types of hydration protocols and we conducted a meta-analysis of magnesium supplementation to understand its effect in protecting against CIN.
A search of the PubMed, Embase, and Cochrane databases was performed. Trials were eligible if they enrolled patients who received cisplatin and different hydration protocols to prevent CIN. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the efficacy of different protocols.
We initially identified 1113 different studies and included 33 of them which met the selection criteria. A meta-analysis of 11 retrospective studies that examined magnesium supplementation during hydration showed that this treatment provided significant protection against CIN (OR = 0.22, 95% CI = 0.14 to 0.35).
There has been uncertainty regarding the best method to prevent CIN. Our results highlight the potentially protective effect of magnesium supplementation during hydration. This study is registered in PROSPERO, CRD42020212682.
肾毒性仍然是顺铂治疗最严重的副作用。顺铂诱导的肾毒性（CIN）限制了这种药物的使用，影响多达20%的患者。几种可能的干预措施，如补充镁，可能预防CIN。本研究旨在回顾不同类型的水化方案，并对补充镁进行荟萃分析，以了解其在预防CIN中的作用。
对PubMed、Embase和Cochrane数据库进行检索。如果试验纳入了接受顺铂和不同水化方案以预防CIN的患者，则该试验符合条件。计算比值比（OR）和95%置信区间（CI）以评估不同方案的疗效。
我们最初识别出1113项不同的研究，其中33项符合入选标准。对11项回顾性研究进行的荟萃分析，这些研究在水化期间检测了补充镁的情况，结果表明这种治疗对CIN有显著的保护作用（OR = 0.22，95% CI = 0.14至0.35）。
关于预防CIN的最佳方法一直存在不确定性。我们的结果突出了水化期间补充镁的潜在保护作用。本研究已在PROSPERO注册，注册号为CRD42020212682。
