评估导致肾毒性的顺铂剂量。
Evaluating dose of cisplatin responsible for causing nephrotoxicity.
机构信息
Department of Biostatistics School of Medicine, Kurume University, Kurume, Fukuoka, Japan.
Department of Pharmacy, Kurume University Hospital, Kurume, Fukuoka, Japan.
出版信息
PLoS One. 2019 Apr 25;14(4):e0215757. doi: 10.1371/journal.pone.0215757. eCollection 2019.
Abstract
Nephrotoxicity is a well-known side effect of cisplatin for cancer treatment. Various regimens have been developed to treat cancer based on the type and severity of the tumor. We focus on the docetaxel, cisplatin, and 5-fluorouracil regimen, which is called the TPF regimen, where the standard dose of cisplatin is 60 mg/m2. The aim of this study is to examine the relationship of the dosage of cisplatin that causes nephrotoxicity and back ground factors of patients using information about the dose of cisplatin actually administered to patients. It is shown that nephrotoxicity may be caused by a substantially smaller dosage than the standard dose of cisplatin in the TPF regimen, indicating the need for dose adjustment, taking into account the patient's background factors in the treatment of a cancer.
摘要
肾毒性是顺铂治疗癌症的已知副作用。已经开发出各种方案来根据肿瘤的类型和严重程度治疗癌症。我们专注于多西紫杉醇、顺铂和 5-氟尿嘧啶方案，称为 TPF 方案，其中顺铂的标准剂量为 60mg/m2。本研究的目的是利用患者实际接受的顺铂剂量信息来检查导致肾毒性的顺铂剂量与患者背景因素之间的关系。结果表明，TPF 方案中，肾毒性可能是由比顺铂标准剂量小得多的剂量引起的，这表明需要根据患者的背景因素调整剂量，以治疗癌症。
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