Regenerative Medicine and Disability Research Lab, University of Illinois College of Medicine, Rockford, IL, USA.
Department of Biomedical Engineering, College of Engineering, University of Illinois , Chicago, IL, USA.
Ann Biomed Eng. 2023 Dec;51(12):2749-2761. doi: 10.1007/s10439-023-03330-x. Epub 2023 Aug 2.
Titanium-based implants utilized in total joint arthroplasties could restore primary musculoskeletal function to patients suffering from osteoarthritis and other conditions. Implants are susceptible to failure stemming from aseptic loosening and infection at the joint site, eventually requiring revision surgery. We hypothesized that there might be a feedback loop by which metal degradation particles and ions released from the implant decrease cell viability and increase immune response, thereby creating biochemical conditions that increase the corrosion rate and release more metal ions. This study focused on the synergistic process through cell viability assays and electrochemical tests. From the results, inflammatory conditions from ion release resulting in cell death would further increase the corrosion rate at the metal implant site. The synergistic interaction in the implant surroundings in which infectious conditions produce Ti ions that contribute to more infection, creating a potential cycle of accelerating corrosion.
钛基植入物在全关节置换术中的应用可以恢复患有骨关节炎和其他疾病的患者的主要肌肉骨骼功能。植入物容易因关节部位的无菌性松动和感染而失效，最终需要进行翻修手术。我们假设可能存在一个反馈回路，即植入物释放的金属降解颗粒和离子会降低细胞活力并增加免疫反应，从而创造出增加腐蚀速率并释放更多金属离子的生化条件。本研究通过细胞活力测定和电化学测试来关注协同过程。从结果来看，离子释放引起的炎症条件会导致细胞死亡，从而进一步增加金属植入部位的腐蚀速率。在植入物环境中存在协同作用，感染条件会产生有助于更多感染的钛离子，从而形成加速腐蚀的潜在循环。
