Department of Plant Pathology and Environmental Microbiology, The Pennsylvania State University, University Park, PA, 16802, USA.
Department of Chemical Engineering, McMaster University, 1280 Main Street, Hamilton, ON, Canada.
Photochem Photobiol Sci. 2023 Nov;22(11):2675-2686. doi: 10.1007/s43630-023-00466-6. Epub 2023 Aug 2.
Antimicrobial resistance in agriculture is a global concern and carries huge financial consequences. Despite that, practical solutions for growers that are sustainable, low cost and environmentally friendly have been sparse. This has created opportunities for the agrochemical industry to develop pesticides with novel modes of action. Recently the use of photodynamic inactivation (PDI), classically used in cancer treatments, has been explored in agriculture as an alternative to traditional chemistries, mainly as a promising new approach for the eradication of pesticide resistant strains. However, applications in the field pose unique challenges and call for new methods of evaluation to adequately address issues specific to PDI applications in plants and challenges faced in the field. The aim of this review is to summarize in vitro, ex vivo, and in vivo/in planta experimental strategies and methods used to test and evaluate photodynamic agents as photo-responsive pesticides for applications in agriculture. The review highlights some of the strategies that have been explored to overcome challenges in the field.
农业中的抗微生物药物耐药性是一个全球性问题，带来了巨大的经济后果。尽管如此，对于种植者来说，可持续、低成本和环保的实用解决方案仍然很少。这为农药行业开发具有新型作用模式的农药创造了机会。最近，光动力失活（PDI）作为传统化学物质的替代品，在农业中被探索作为一种替代方法，主要是作为消除抗农药菌株的有前途的新方法。然而，在田间应用带来了独特的挑战，需要新的评估方法来充分解决 PDI 在植物中的应用以及在田间面临的挑战的具体问题。本综述的目的是总结用于测试和评估光动力剂作为光响应性农药在农业中应用的体外、离体和体内/植物内实验策略和方法。该综述强调了一些已探索的策略，以克服田间的挑战。
