Hughes J M, Hichens M, Booze G W, Thorner M O
Arch Intern Med. 1986 Sep;146(9):1848-9.
We present, to our knowledge, the first case of Cushing's syndrome due to large doses of intramuscular dexamethasone acetate. Dexamethasone levels after intramuscular dexamethasone administration were measured in two patients. Serial determination of the dexamethasone levels demonstrated prolonged serum half-lives of seven and 33 days in the two patients, respectively. Furthermore, pharmacologic levels of dexamethasone were present as long as seven months after the initial injections. The present recommendation for the use of intramuscular dexamethasone acetate is as frequent as every one to three weeks. However, our patients demonstrate that supraphysiologic levels of dexamethasone may still be present well beyond the three-week period.
据我们所知，我们报告了首例因大剂量肌肉注射醋酸地塞米松导致的库欣综合征病例。对两名患者进行了肌肉注射地塞米松后地塞米松水平的测定。连续测定地塞米松水平显示，两名患者的血清半衰期分别延长至7天和33天。此外，在首次注射后长达7个月的时间里，地塞米松水平一直维持在药理水平。目前关于肌肉注射醋酸地塞米松的使用建议是每1至3周注射一次。然而，我们的患者表明，在三周之后，地塞米松的超生理水平可能仍然存在。
