Joint Research Centre on Medicine, the Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang 315700, China; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Phytomedicine. 2023 Oct;119:154987. doi: 10.1016/j.phymed.2023.154987. Epub 2023 Jul 20.
Hyperglycemic induced cardiac hypertrophy and cardiac inflammation are important pathological processes in diabetic cardiomyopathy. β-elemene (Ele) is a natural compound extracted from Curcuma Rhizoma and has anti-tumor effects. It also has therapeutic effects in some inflammatory diseases. However, the therapeutic effect of Ele on diabetic cardiomyopathy is not clear. The purpose of this study was to evaluate the effect of Ele on hyperglycemia-caused cardiac remodeling and heart failure.
C57BL/6 mice were intraperitoneally injected with streptozotocin to induce DCM, and Ele was administered intragastric after 8 weeks to investigate the effect of Ele. RNA sequencing of cardiac tissue was performed to investigate the mechanism.
Ele markedly inhibited cardiac inflammation, fibrosis and hypertrophy in diabetic mice, as well as in high glucose-induced cardiomyocytes. RNA sequencing showed that cardioprotective effect of Ele involved the JAK/STAT3-NF-κB signaling pathway. Ele alleviated heart and cardiomyocyte inflammation in mice by blocking diabetes-induced JAK2 and STAT3 phosphorylation and NF-κB activation.
The study found that Ele preserved the hearts of diabetic mice by inhibiting JAK/STAT3 and NF-κB mediated inflammatory responses, suggesting that Ele is an effective therapy for DCM.
高血糖诱导的心肌肥大和心肌炎症是糖尿病心肌病的重要病理过程。β-榄香烯（Ele）是从莪术根茎中提取的天然化合物，具有抗肿瘤作用。它在一些炎症性疾病中也有治疗作用。然而，Ele 对糖尿病心肌病的治疗效果尚不清楚。本研究旨在评价 Ele 对高血糖引起的心脏重构和心力衰竭的作用。
C57BL/6 小鼠腹腔注射链脲佐菌素诱导 DCM，8 周后给予 Ele 灌胃，以探讨 Ele 的作用。对心脏组织进行 RNA 测序，以探讨其作用机制。
Ele 明显抑制了糖尿病小鼠以及高糖诱导的心肌细胞中的心肌炎症、纤维化和肥大。RNA 测序显示，Ele 的心脏保护作用涉及 JAK/STAT3-NF-κB 信号通路。Ele 通过阻断糖尿病诱导的 JAK2 和 STAT3 磷酸化以及 NF-κB 激活，减轻了小鼠的心脏和心肌细胞炎症。
本研究发现 Ele 通过抑制 JAK/STAT3 和 NF-κB 介导的炎症反应来保护糖尿病小鼠的心脏，表明 Ele 是治疗 DCM 的有效方法。
