Parihar Akshay, Prajapati Bhupendra G, Paliwal Himanshu, Shukla Maheka, Khunt Dignesh, Devrao Bahadure Sumedh, Dyawanapelly Sathish, Junnuthula Vijayabhaskarreddy
Faculty of Pharmaceutical Sciences, The ICFAI University, Baddi, Himachal Pradesh, India.
Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana, Gujarat, India.
Drug Discov Today. 2023 Oct;28(10):103729. doi: 10.1016/j.drudis.2023.103729. Epub 2023 Jul 31.
Cystic fibrosis (CF), a fatal genetic condition, causes thick, sticky mucus. It also causes pancreatic dysfunction, bacterial infection, and increased salt loss. Currently available treatments can improve the patient's quality of life. Drug delivery aided by nanotechnology has been explored to alter the pharmacokinetics and toxicity of drugs. In this short review, we aim to summarize various conventional formulations and highlight advanced formulations delivered via the pulmonary route for the treatment of CF. There is considerable interest in advanced drug delivery formulations addressing the various challenges posed by CF. Despite their potential to be translated for clinical use, we anticipate that a significant amount of effort may still be required for translation to the clinic.
囊性纤维化（CF）是一种致命的遗传疾病，会导致黏稠的黏液产生。它还会引起胰腺功能障碍、细菌感染以及盐分流失增加。目前可用的治疗方法可以改善患者的生活质量。人们已经探索了借助纳米技术的药物递送方式来改变药物的药代动力学和毒性。在这篇简短的综述中，我们旨在总结各种传统制剂，并重点介绍通过肺部途径递送用于治疗CF的先进制剂。针对CF带来的各种挑战的先进药物递送制剂引起了人们极大的兴趣。尽管它们有转化为临床应用的潜力，但我们预计仍可能需要大量努力才能转化到临床应用。
