[Changes in the acid phosphatase activity in skeletal muscles in temporary acute ischemia of the extremities and in early postischemic recirculation].

Acid phosphatase (APh) activity has been experimentally studied on 69 dogs in the musculus soleus during ischemic and postischemic periods. Absence of an essential APh activation demonstrates a complete adaptation and stabilization of the intracellular mechanisms of homeostasis under an acute 3 hours' ischemia. Under a prolonged (6, 9, 12 h) ischemia APh activity in sarcoplasm of the muscle fibers increases considerably. This is, probably, one of the signs demonstrating structural-metabolic disadaptation and beginning of irreversible lesions. The data obtained make it possible to conclude that it is necessary to perform operative restoration of the blood stream in the extremities at early stages of ischemia.