Medical University Sofia, Sofia, Bulgaria
Department of Medical Oncology, Medical University of Sofia, Sofia, Bulgaria.
BMJ Open. 2023 Aug 2;13(8):e068431. doi: 10.1136/bmjopen-2022-068431.
This study focused on Bulgarian patient cohorts harbouring a single documented chronic comorbidity-cardiovascular pathology, an oncological disease or a chronic pulmonary diseases (CPD) comparing the outcomes in fully vaccinated and non-vaccinated populations classified by sex and age groups in ambulatory, hospital and intensive care unit (ICU) settings at the national level.
Retrospective analysis SETTINGS, PARTICIPANTS AND OUTCOME MEASURES: In total, 1 126 946 patients with confirmed COVID-19, on a national level, were retrospectively analysed between March 2020 and April 2022, using data from the Ministry of Health's United Information Portal, launched in March 2020.
Of all the confirmed 247 441 hospitalised cases of COVID-19, 67 723 (27.3%) had documented cardiovascular disease (CVD), 2140 (0.9%) had confirmed solid malignancy (regardless of stage) and 3243 (1.3%) had established CPD as their only chronic pathology. The number of cumulative deaths in each subgroup was 10 165 (in-hospital=5812 and ICU=4353); 4.0% vaccinated (410/10 165, p<0.001), 344 (in-hospital=196 and ICU=148), 4.9% vaccinated (17/344, p<0.001), 494 (in-hospital=287 and ICU=207) and 5.2% vaccinated (26/494, p<0.001), respectively. Statistical significance (p<0.001) was obtained in favour of reduced ambulatory, hospitalisation and both in-hospital and ICU-related mortality in the vaccinated cohorts, and BNT162b2 was the most effective at preventing mortality in all age groups.
This retrospective analysis shows that patients vaccinated against COVID-19 demonstrated trends of reduced hospitalisations and premature mortality in patients with CVD, solid malignancy or CPD as a single comorbidity.
本研究聚焦于保加利亚的患者队列，这些患者患有单一记录的慢性合并症——心血管疾病、肿瘤疾病或慢性肺部疾病（CPD），并比较了按性别和年龄组分类的在门诊、住院和重症监护病房（ICU）环境下完全接种疫苗和未接种疫苗人群的结局，这是在国家层面上进行的。
回顾性分析
设置、参与者和结局测量：2020 年 3 月至 2022 年 4 月期间，我们在国家层面上使用卫生部于 2020 年 3 月推出的联合信息门户的数据，对总共 1126946 例确诊的 COVID-19 患者进行了回顾性分析。
在所有确诊的 247441 例住院 COVID-19 病例中，67723 例（27.3%）有记录的心血管疾病（CVD），2140 例（0.9%）有明确的实体恶性肿瘤（无论分期如何），3243 例（1.3%）有明确的 CPD 作为唯一的慢性疾病。每个亚组的累积死亡人数为 10165 例（住院=5812 例和 ICU=4353 例）；4.0%接种疫苗（410/10165，p<0.001），344 例（住院=196 例和 ICU=148 例），4.9%接种疫苗（17/344，p<0.001），494 例（住院=287 例和 ICU=207 例）和 5.2%接种疫苗（26/494，p<0.001）。接种疫苗的队列在门诊、住院和住院及 ICU 相关死亡率方面均显示出降低的趋势，差异具有统计学意义（p<0.001），并且 BNT162b2 在所有年龄组中预防死亡率的效果最为显著。
这项回顾性分析表明，在 CVD、实体恶性肿瘤或 CPD 作为单一合并症的患者中，接种 COVID-19 疫苗的患者表现出住院和过早死亡减少的趋势。
