Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Department of Endocrinology, Taizhou People's Hospital, Taizhou, China.
J Diabetes. 2023 Nov;15(11):978-986. doi: 10.1111/1753-0407.13450. Epub 2023 Aug 2.
Interleukin (IL)-10 plays a notable role in the inflammatory-associated mild cognitive impairment (MCI). We aimed to investigate whether IL-10 and its upstream factors exert an impact on MCI in type 2 diabetes mellitus (T2DM) patients.
A total of 117 T2DM patients were recruited and divided into Control group and MCI group based on the presence or absence of MCI. Clinical parameters were collected. The Montreal Cognitive Assessment (MoCA) was conducted for global cognitive function. Digit Span Test (DST), Verbal Fluency Test (VFT), and Trail Making Test-B (TMTB) were used to evaluate the executive functions of the diabetic patients. Trail Making Test-A (TMTA) was performed to examine the information processing speed function. Patients' scene memory was examined by Logical Memory Test (LMT). After the baseline data were compared, correlation and regression analyses were performed to explore the relationship among IL-10, miR-let-7c-5p and cognitive function.
Compared to 80 patients in the control group, 37 patients in the MCI group exhibited lower IL-10 in plasma and higher miR-let-7c-5p levels in exosomes from plasma. The IL-10 level was negatively associated with MoCA. Likewise, miR-let-7c-5p levels were negatively correlated with IL-10 levels and MoCA. Elevated miR-let-7c-5p levels and decreased IL-10 levels are risk factors for MCI in T2DM patients. Increased miR-let-7c-5p and downregulated IL-10 may influence VFT and TMTB, respectively, associated with executive function.
We demonstrated that IL-10 is correlated to the executive function of T2DM patients. Decreased IL-10 may result from the regulation of miR-let-7c-5p in exosomes.
白细胞介素（IL）-10 在与炎症相关的轻度认知障碍（MCI）中起着显著作用。我们旨在研究白细胞介素-10 及其上游因素是否对 2 型糖尿病（T2DM）患者的 MCI 产生影响。
共招募了 117 名 T2DM 患者，根据是否存在 MCI 将其分为对照组和 MCI 组。收集临床参数。采用蒙特利尔认知评估（MoCA）评估总体认知功能。进行数字跨度测试（DST）、言语流畅性测试（VFT）和连线测试 B（TMTB）评估糖尿病患者的执行功能。进行连线测试 A（TMTA）以检查信息处理速度功能。通过逻辑记忆测试（LMT）检查患者的场景记忆。在比较基线数据后，进行相关性和回归分析，以探讨 IL-10、miR-let-7c-5p 与认知功能之间的关系。
与对照组的 80 名患者相比，MCI 组的 37 名患者的血浆中 IL-10 水平较低，而血浆来源的外泌体中 miR-let-7c-5p 水平较高。IL-10 水平与 MoCA 呈负相关。同样，miR-let-7c-5p 水平与 IL-10 水平和 MoCA 呈负相关。升高的 miR-let-7c-5p 水平和降低的 IL-10 水平是 T2DM 患者 MCI 的危险因素。miR-let-7c-5p 的增加和 IL-10 的下调可能分别影响 VFT 和 TMTB，与执行功能相关。
我们证明了白细胞介素-10 与 T2DM 患者的执行功能有关。IL-10 的减少可能是由于外泌体中 miR-let-7c-5p 的调节所致。
