Rehabilitation Medicine Department, The Affiliated Hospital of Southwest Medical University, Lu Zhou, Sichuan, People's Republic of China.
The People's Hospital in Longmatan District of Luzhou, Sichuan, People's Republic of China.
J Cutan Med Surg. 2023 Sep-Oct;27(5):504-508. doi: 10.1177/12034754231191461. Epub 2023 Aug 2.
Platelet-rich plasma (PRP) contains a variety of growth factors and has been widely used in maxillofacial surgery, orthopedics, plastic surgery, ophthalmology, and other fields. In recent years, with the increasing morbidity of androgenetic alopecia (AGA), the use of PRP has also increased. The objective of this article was to evaluate the efficacy and safety of PRP for AGA. We searched PubMed, Embase, Web of Science, and Cochrane Library, covering the databases from their earliest records until March 2022. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to explore the effects of PRP for hair density, hair count, and hair diameter in AGA. Nine trials involving 238 patients were included. The meta-analysis showed that PRP for AGA increased hair density at 3 and 6 months with statistically significant differences compared with the placebo ( < .05). PRP also increased hair count and hair diameter compared with the baseline, but there was no significant difference compared with the placebo ( > .05). Two of the 7 studies reported adverse reactions. No serious adverse reactions were found. In conclusion, PRP is an effective and safe treatment for increasing the hair density in AGA. Trial registration: The systematic review was registered with PROSPERO (CRD42022362432).
富血小板血浆（PRP）含有多种生长因子，已广泛应用于颌面外科、骨科、整形科、眼科等领域。近年来，随着雄激素性脱发（AGA）发病率的增加，PRP 的应用也有所增加。本文旨在评估 PRP 治疗 AGA 的疗效和安全性。我们检索了 PubMed、Embase、Web of Science 和 Cochrane Library，涵盖了从最早记录到 2022 年 3 月的数据库。我们对随机对照试验（RCT）进行了系统评价和荟萃分析，以探讨 PRP 对 AGA 患者的头发密度、头发计数和头发直径的影响。纳入了 9 项涉及 238 例患者的试验。荟萃分析显示，与安慰剂相比，PRP 治疗 AGA 可在 3 个月和 6 个月时显著增加头发密度（<.05）。PRP 还可增加头发计数和头发直径，但与安慰剂相比无显著差异（>.05）。7 项研究中有 2 项报告了不良反应。未发现严重不良反应。结论：PRP 是一种有效且安全的治疗方法，可增加 AGA 患者的头发密度。试验注册：本系统评价已在 PROSPERO（CRD42022362432）上注册。
