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无菌性骨不连和严重骨缺损的治疗：让我们使这一情况愈合！

Management of aseptic nonunions and severe bone defects: let us get this thing healed!

作者信息

Nauth Aaron, Crist Brett D, Morshed Saam, Watson J Tracy, Pape Hans-Christoph

机构信息

Department of Orthopaedic Surgery, University of Toronto, Toronto, ON, Canada.

Department of Orthopaedic Surgery, One Hospital, Columbia, MO.

出版信息

OTA Int. 2023 Jun 16;6(3 Suppl):e258. doi: 10.1097/OI9.0000000000000258. eCollection 2023 Jun.

DOI:10.1097/OI9.0000000000000258
PMID:37533443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10392436/
Abstract

Effective nonunion and bone defect management requires consideration of multiple potential contributing factors including biomechanics, biology, metabolic, and patient factors. This article reviews these factors as well as several potential nonunion or bone defect treatments including bone grafts, bone graft substitutes, the induced membrane technique, and distraction osteogenesis. A summary of these concepts and guidelines for an overall approach to management are also provided.

摘要

有效的骨不连和骨缺损治疗需要考虑多种潜在的促成因素，包括生物力学、生物学、代谢和患者因素。本文回顾了这些因素以及几种潜在的骨不连或骨缺损治疗方法，包括骨移植、骨移植替代物、诱导膜技术和牵张成骨。还提供了这些概念的总结以及整体治疗方法的指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ce/10392436/0df0b2a4b4a4/oi9-6-e258-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ce/10392436/7ce05c516bc1/oi9-6-e258-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ce/10392436/790eb99ddb5c/oi9-6-e258-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ce/10392436/0df0b2a4b4a4/oi9-6-e258-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ce/10392436/7ce05c516bc1/oi9-6-e258-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ce/10392436/790eb99ddb5c/oi9-6-e258-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ce/10392436/0df0b2a4b4a4/oi9-6-e258-g003.jpg

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本文引用的文献

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2
Hardware considerations in infection and nonunion management: When and how to revise the fixation.感染与骨不连治疗中的硬件考量：何时以及如何翻修内固定
OTA Int. 2020 Mar 23;3(1):e055. doi: 10.1097/OI9.0000000000000055. eCollection 2020 Mar.
3
A Randomized Controlled Trial Comparing rhBMP-2/Absorbable Collagen Sponge Versus Autograft for the Treatment of Tibia Fractures With Critical Size Defects.
光生物调节疗法可改善由无机骨基质和纤维蛋白异源生物聚合物填充的骨缺损的修复。
Bioengineering (Basel). 2024 Jan 13;11(1):78. doi: 10.3390/bioengineering11010078.
rhBMP-2/可吸收胶原海绵与自体骨移植治疗伴有临界尺寸缺损的胫骨骨折的随机对照试验。
J Orthop Trauma. 2019 Aug;33(8):384-391. doi: 10.1097/BOT.0000000000001492.
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Autograft, Allograft, and Bone Graft Substitutes: Clinical Evidence and Indications for Use in the Setting of Orthopaedic Trauma Surgery.自体移植物、同种异体移植物和骨移植替代物：在骨科创伤外科中使用的临床证据和适应证。
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