Division of Orthopaedic Surgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Division of Orthopaedic Surgery, University of Western Ontario, London, ON, Canada.
J Orthop Trauma. 2018 Mar;32 Suppl 1:S7-S11. doi: 10.1097/BOT.0000000000001115.
There is a significant burden of disease associated with bone defects, and their management is challenging. These injuries have a profound clinical and economic impact, and outcomes are limited by high rates of complication and reoperation, as well as poor functional outcomes. There remains a lack of consensus around definitions, reliable models, and best practices for the surgical management of bone defects. The current state of the literature on bone defects is reviewed here, with a focus on defining critical-size bone defect, the use of the induced membrane technique, the role of biologics, and the management of infected bone defects.
骨缺损相关的疾病负担巨大，其治疗极具挑战性。这些损伤具有深远的临床和经济影响，且由于高并发症和再手术率以及较差的功能结果，治疗结局受限。在骨缺损的外科治疗方面，定义、可靠模型和最佳实践仍缺乏共识。本文回顾了骨缺损相关文献的现状，重点讨论临界尺寸骨缺损的定义、诱导膜技术的应用、生物制剂的作用以及感染性骨缺损的处理。
