Ertay Ayse, Ewing Rob M, Wang Yihua
Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Genes Dis. 2023 Nov;10(6):2511-2527. doi: 10.1016/j.gendis.2022.12.015.
() is a tumour suppressor gene and has a role in inhibiting the oncogenic AKT signalling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP) into phosphatidylinositol 4,5-bisphosphate (PIP). The function of PTEN is regulated by different mechanisms and inactive PTEN results in aggressive tumour phenotype and tumorigenesis. Identifying targeted therapies for inactive tumour suppressor genes such as has been challenging as it is difficult to restore the tumour suppressor functions. Therefore, focusing on the downstream signalling pathways to discover a targeted therapy for inactive tumour suppressor genes has highlighted the importance of synthetic lethality studies. This review focuses on the potential synthetic lethality genes discovered in PTEN-inactive cancer types. These discovered genes could be potential targeted therapies for PTEN-inactive cancer types and may improve the treatment response rates for aggressive types of cancer.
（）是一种肿瘤抑制基因，通过将磷脂酰肌醇3,4,5 - 三磷酸（PIP）去磷酸化为磷脂酰肌醇4,5 - 二磷酸（PIP），在抑制致癌性AKT信号通路中发挥作用。PTEN的功能受不同机制调控，PTEN失活会导致侵袭性肿瘤表型和肿瘤发生。由于难以恢复肿瘤抑制功能，为诸如失活的肿瘤抑制基因寻找靶向治疗一直具有挑战性。因此，专注于下游信号通路以发现针对失活肿瘤抑制基因的靶向治疗凸显了合成致死性研究的重要性。本综述聚焦于在PTEN失活的癌症类型中发现的潜在合成致死基因。这些发现的基因可能是PTEN失活癌症类型的潜在靶向治疗方法，并可能提高侵袭性癌症类型的治疗反应率。
