Abdullah Al Awadh Ahmed
Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, 1988, Najran 61441, Saudi Arabia.
Saudi Pharm J. 2023 Sep;31(9):101698. doi: 10.1016/j.jsps.2023.101698. Epub 2023 Jul 7.
Indole, benzoxazole benzothiazole and benzimidazole are excellent classes of organic heterocyclic compounds. These compounds show significant application in pharmacy, industries, dyes, medicine, polymers and food packages. These compounds also form metal complexes with copper, zinc, cadmium, nickel, cobalt, platinum, gold, palladium chromium, silver, iron, and other metals that have shown to be significant applications. Recently, researchers have attracted enormous attention toward heterocyclic compounds such as indole, benzimidazole, benzothiazole, benzoxazole, and their complexes due to their excellent medicinal applications such as anti-ulcerogenic, anti-cancer, antihypertensive, antifungal, anti-inflammatory, antitubercular, antiparasitic, anti-obesity, antimalarial, antiglycation, antiviral potency, antineuropathic, analgesic antioxidant, antihistaminic, and antibacterial potentials. In this article, we summarize the medicinal applications of these compounds as well as their metal complexes. We hope this article will help researchers in designing and synthesizing novel and potent compounds with significant applications in various fields.
吲哚、苯并恶唑、苯并噻唑和苯并咪唑是优良的有机杂环化合物类别。这些化合物在制药、工业、染料、医学、聚合物和食品包装等领域有重要应用。这些化合物还能与铜、锌、镉、镍、钴、铂、金、钯、铬、银、铁及其他金属形成金属配合物，且已显示出重要应用。近来，由于吲哚、苯并咪唑、苯并噻唑、苯并恶唑及其配合物具有诸如抗溃疡、抗癌、抗高血压、抗真菌、抗炎、抗结核、抗寄生虫、抗肥胖、抗疟疾、抗糖化、抗病毒、抗神经病变、镇痛抗氧化、抗组胺和抗菌等优良药用性能，研究人员对它们给予了极大关注。在本文中，我们总结了这些化合物及其金属配合物的药用应用。我们希望本文将有助于研究人员设计和合成在各个领域有重要应用的新型高效化合物。
