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自体骨髓抽吸浓缩液增强的半月板同种异体移植

Meniscus Allograft Transplantation Augmented With Autologous Bone Marrow Aspirate Concentrate.

作者信息

Morgan Courtney, Bell Ryan, Burland Julie P, Edgar Cory M

机构信息

Department of Orthopaedic Surgery, University of Connecticut, Farmington, Connecticut, U.S.A.

UConn Institute for Sports Medicine, University of Connecticut, Farmington, Connecticut, U.S.A.

出版信息

Arthrosc Tech. 2023 Jun 5;12(7):e1021-e1026. doi: 10.1016/j.eats.2023.02.043. eCollection 2023 Jul.

DOI:10.1016/j.eats.2023.02.043
PMID:37533910
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10390746/
Abstract

Meniscus allograft transplantation (MAT) has been shown to be a feasible surgical option for younger patients, below 50 years of age who have meniscal insufficiency and have failed conservative treatment measures. In this technical note, we describe a procedure of harvesting and injecting bone marrow aspirate concentrate in a meniscus allograft during a MAT procedure, which may allow for longer lasting transplants and improve patient outcomes. In this technical note, bone marrow aspirate concentrate is harvested arthroscopically from the intercondylar notch at the surgical site, which prevents additional donor site morbidity, as seen with harvesting from other locations, such as the iliac crest. This also reduces operating time, since harvesting from the iliac crest requires different patient positioning and usually additional anesthesia. The authors of this surgical technique believe that biological augmentation during MATs will assist surgeons in maximizing graft survivorship and, ultimately, lead to better patient outcomes.

摘要

半月板同种异体移植(MAT)已被证明是50岁以下半月板功能不全且保守治疗措施失败的年轻患者可行的手术选择。在本技术说明中,我们描述了在MAT手术过程中采集和注射骨髓抽吸浓缩物到半月板同种异体移植物中的过程,这可能使移植更持久,并改善患者预后。在本技术说明中,骨髓抽吸浓缩物通过关节镜从手术部位的髁间切迹采集,这避免了从其他部位(如髂嵴)采集时出现的额外供区并发症。这也减少了手术时间,因为从髂嵴采集需要不同的患者体位,通常还需要额外的麻醉。这种手术技术的作者认为,MAT期间的生物增强将有助于外科医生最大限度地提高移植物存活率,并最终带来更好的患者预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2927/10390746/b9bedb103457/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2927/10390746/f67d057f65ad/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2927/10390746/badd9cc3dce6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2927/10390746/b9bedb103457/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2927/10390746/f67d057f65ad/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2927/10390746/badd9cc3dce6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2927/10390746/b9bedb103457/gr4.jpg

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本文引用的文献

1
Implantation of Novel Meniscus Scaffold for Irreparable Meniscal Tear.新型半月板支架植入治疗不可修复的半月板撕裂
Arthrosc Tech. 2022 Apr 22;11(5):e775-e779. doi: 10.1016/j.eats.2021.12.036. eCollection 2022 May.
2
Lateral Meniscus Allograft Transplantation in Combination with BMAC (Bone Marrow Aspirate Concentrate) Injection: Biologic Augmentation of the Allograft.同种异体外侧半月板移植联合骨髓抽吸浓缩物注射:同种异体移植的生物增强
Arthrosc Tech. 2022 Apr 22;11(5):e767-e773. doi: 10.1016/j.eats.2021.12.035. eCollection 2022 May.
3
Arthroscopic Segmental Medial Meniscus Allograft Transplant Using Three Fixation Techniques.
使用三种固定技术的关节镜下节段性内侧半月板同种异体移植术
Arthrosc Tech. 2021 Oct 16;10(11):e2507-e2513. doi: 10.1016/j.eats.2021.07.035. eCollection 2021 Nov.
4
Lateral Meniscal Allograft Transplant: Dovetail Bone Bridge Preparation.外侧半月板同种异体移植:燕尾形骨桥制备
Arthrosc Tech. 2021 Feb 22;10(4):e969-e973. doi: 10.1016/j.eats.2020.11.008. eCollection 2021 Apr.
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Surgical treatment of complex meniscus tear and disease: state of the art.复杂半月板撕裂和疾病的外科治疗:现状。
J ISAKOS. 2021 Jan;6(1):35-45. doi: 10.1136/jisakos-2019-000380. Epub 2020 Sep 17.
6
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Orthop J Sports Med. 2020 Sep 9;8(9):2325967120950306. doi: 10.1177/2325967120950306. eCollection 2020 Sep.
7
Meniscal allograft transplantation: a review of indications, techniques, and outcomes.半月板同种异体移植:适应证、技术和结果的综述。
Knee Surg Sports Traumatol Arthrosc. 2020 Nov;28(11):3539-3550. doi: 10.1007/s00167-020-06058-6. Epub 2020 May 15.
8
The results of meniscal allograft transplantation surgery: what is success?半月板同种异体移植手术的结果:何为成功?
BMC Musculoskelet Disord. 2020 Mar 12;21(1):159. doi: 10.1186/s12891-020-3165-0.
9
Meniscal Allograft Transplantation: Indications, Techniques, Outcomes.半月板同种异体移植:适应证、技术、结果。
Arthroscopy. 2020 Apr;36(4):938-939. doi: 10.1016/j.arthro.2020.01.025.
10
The Meniscus Tear: A Review of Stem Cell Therapies.半月板撕裂:干细胞疗法综述。
Cells. 2019 Dec 30;9(1):92. doi: 10.3390/cells9010092.