Moura Alves Seixas Gabriel, de Souza Freitas Renata, Ferreira Fratelli Caroline, de Souza Silva Calliandra Maria, Ramos de Lima Luciano, Morato Stival Marina, Schwerz Funghetto Silvana, Rodrigues da Silva Izabel Cristina
Graduate Program in Health Sciences and Technologies, Faculty of Ceilândia, University of Brasilia, Federal District, Brasília, Brazil.
University Center of Brasília (UniCEUB), Brasília, Brazil.
J Aging Res. 2023 Jul 25;2023:8538027. doi: 10.1155/2023/8538027. eCollection 2023.
Monoamine oxidase (MAO) is involved in several biological processes associated with well-being and mental health, and alterations in its function might directly impact various mental disorders. Some mental disorders concomitantly occur in individuals with clinical characteristics, such as substance abuse and diabetes.
To analyze the functional MAOA uVNTR polymorphism genotype frequency in an older adult population with diabetes mellitus/arterial hypertension and associate this frequency with clinical characteristics impacting daily life. . Older adults diagnosed with diabetes mellitus, systemic arterial hypertension, or both (DM/SAH) were selected and had their MAOA gene genotyped for uVNTR polymorphism. The revised Beck Depression Inventory (BDI) and a questionnaire were also applied to determine their mental health and clinical characteristics.
The allelic variants detected among the participants were the 2R, 3R, 4R, and 3R/4R heterozygous genotypes. Genotypes solely containing the 3R allele had patients who marked yes for smoking and alcoholism, and only those with the 3R genotypes (female 3R/3R homozygote or male 3R hemizygote) were significant. Although not statistically significant, only 3R and 3R/4R genotypes presented cases of severe depression per the revised BDI interpretations.
The MAOA uVNTR polymorphism's low-activity 3R allele presence in an older adult population diagnosed with DM/SAH may represent a risk for developing substance use (alcohol and smoking) dependence.
单胺氧化酶（MAO）参与了与幸福感和心理健康相关的多个生物学过程，其功能改变可能直接影响各种精神障碍。一些精神障碍在具有诸如药物滥用和糖尿病等临床特征的个体中同时出现。
分析患有糖尿病/动脉高血压的老年人群中功能性单胺氧化酶A可变数目串联重复序列（MAOA uVNTR）多态性的基因型频率，并将该频率与影响日常生活的临床特征相关联。选择被诊断患有糖尿病、系统性动脉高血压或两者皆有的老年人（DM/SAH），对其MAOA基因进行uVNTR多态性基因分型。还应用修订版贝克抑郁量表（BDI）和一份问卷来确定他们的心理健康状况和临床特征。
在参与者中检测到的等位基因变体为2R、3R、4R以及3R/4R杂合基因型。仅含有3R等位基因的基因型中，患者在吸烟和酗酒问题上回答为“是”，且只有那些具有3R基因型的患者（女性3R/3R纯合子或男性3R半合子）具有统计学意义。根据修订版BDI的解释，虽然无统计学意义，但只有3R和3R/4R基因型出现了重度抑郁病例。
在被诊断患有DM/SAH的老年人群中，MAOA uVNTR多态性低活性3R等位基因的存在可能代表着发生物质使用（酒精和吸烟）依赖的风险。
