Tian Dachen, Zhao Xuan, Ning Zhaoteng, Gong Zixiang, Wu Jincheng, Wang Xianjun
Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong, China.
Department of Neurology, Linyi People's Hospital Affiliated to Shandong First Medical University, Linyi, Shandong, China.
Heliyon. 2023 Jul 19;9(8):e18430. doi: 10.1016/j.heliyon.2023.e18430. eCollection 2023 Aug.
Exposure to Migraine may be one of the risk factors for the onset of rheumatoid arthritis (RA), while the relationship between the two is debatable. In this study, the connection between migraine and the risk of RA was investigated using a systematic review and meta-analysis of the pertinent literature.
Up to July 2022, the PubMed, EMBASE, Web of Science (WOS), and scopus databases were employed to search for observational studies on the risk of RA in migraineurs. The effect sizes were pooled using a random-effects model or a fixed-effects model.
Out of 2345 records, 5 studies (3 case and control studies and 2 cohort studies) were identified and included in the meta-analysis. According to a pooled analysis, migraine sufferers had a higher chance of developing RA (pooled adjusted effect estimate: 1.94, 95% confidence interval: 1.74-2.17; p < 0.01).
Migraine can be legitimately regarded as a risk factor for RA since this study demonstrated a relationship between migraine and RA. This conclusion should be treated with caution due to low power and precision. Rigorous design and larger sample sizes of studies are needed to verify the findings.
偏头痛可能是类风湿关节炎（RA）发病的危险因素之一，然而两者之间的关系仍存在争议。在本研究中，通过对相关文献进行系统评价和荟萃分析，探讨偏头痛与RA风险之间的联系。
截至2022年7月，使用PubMed、EMBASE、科学网（WOS）和Scopus数据库检索关于偏头痛患者患RA风险的观察性研究。采用随机效应模型或固定效应模型合并效应量。
在2345条记录中，识别出5项研究（3项病例对照研究和2项队列研究）并纳入荟萃分析。根据汇总分析，偏头痛患者患RA的可能性更高（汇总调整效应估计值：1.94，95%置信区间：1.74 - 2.17；p < 0.01）。
由于本研究证明了偏头痛与RA之间的关系，偏头痛可被合理视为RA的一个危险因素。鉴于研究的低效能和低精度，该结论应谨慎对待。需要严格设计和更大样本量的研究来验证这些发现。
