Yu Tianzhuo, Zhang Lin, Xu Jianping, Meng Jun, Yu Xiulei, Zhang Ying
Department of Ultrasonography, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Zhejiang Integrated Traditional and Western Medicine Hospital, Hangzhou Red Cross Hospital, Hangzhou, China.
Front Med (Lausanne). 2023 Jul 18;10:1177045. doi: 10.3389/fmed.2023.1177045. eCollection 2023.
In order to research the value of multimodal ultrasonography in evaluating therapeutic response of cervical tuberculous lymphadenitis to anti-tuberculosis drugs.
Sixty-one patients with cervical tuberculous lymphadenitis were enrolled in this study. Ultrasound examination was performed before systemic standard anti-tuberculosis treatment and within 1-2 months after treatment, and the patients were divided into effective group and ineffective group according to the follow-up at the sixth month. The multimodal ultrasound signs of the two groups were compared and analyzed.
In the effective group, there were significant differences in the maximum diameter of lymph nodes, the echo of the surrounding tissue and the enlargement of the contrast area before and after treatment ( < 0.05). At 1-2 months after treatment, there were significant differences in the maximum diameter, pus changes, CDFI, elasticity scores, echo of surrounding tissues, changes in enlarged and non-enhanced areas after contrast enhancement between the effective group and the ineffective group ( < 0.05).
The multimodal ultrasound signs of the appearance of internal pus or non-enhancement area enlargement, enhanced echo of the surrounding tissue and enlargement after CEUS are related to poor prognosis, and may be used to evaluate the response of anti-tuberculosis chemotherapy when the size change of lymph node is not obvious in individual treatment.
探讨多模态超声在评估颈部结核性淋巴结炎抗结核药物治疗效果中的价值。
本研究纳入61例颈部结核性淋巴结炎患者。在全身标准抗结核治疗前及治疗后1 - 2个月进行超声检查，并根据第六个月的随访情况将患者分为有效组和无效组。对两组的多模态超声征象进行比较分析。
有效组治疗前后淋巴结最大径、周围组织回声及造影剂增强区域扩大情况差异有统计学意义（<0.05）。治疗后1 - 2个月，有效组与无效组在最大径、脓液变化、CDFI、弹性评分、周围组织回声、造影增强后扩大及无增强区域变化方面差异有统计学意义（<0.05）。
内部出现脓液或无增强区域扩大、周围组织回声增强及CEUS后增大等多模态超声征象与预后不良有关，在个体治疗中当淋巴结大小变化不明显时，可用于评估抗结核化疗的反应。
