Vahabi Arman, Mert Merve, Erdem Hüseyin Aytaç, Yıldırım Şimşir Ilgın, Taşbakan Meltem Işıkgöz, Öztürk Anıl Murat
Ege University School of Medicine, Department of Orthopedics and Traumatology, İzmir, Turkey.
Ege University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, İzmir, Turkey.
Interdiscip Perspect Infect Dis. 2023 Jul 25;2023:9154038. doi: 10.1155/2023/9154038. eCollection 2023.
The purpose of this study is to evaluate the side effects associated with hyperbaric oxygen therapy and provide recommendations to prevent them in patients with diabetic foot ulcers.
The use of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers remains a contentious issue, and minimizing side effects is critical. While the incidence of side effects related to hyperbaric oxygen (HBO) therapy is low, it is essential to evaluate cases in a multifaceted and interdisciplinary manner to prevent adverse outcomes.
A retrospective cohort study was conducted over the period of 2018-2020, involving a dataset of 100 patients. The primary objective of the study was to examine the frequency and types of side effects experienced by patients who underwent hyperbaric oxygen therapy (HBO) for diabetic foot ulcers (DFUs). In addition, we analyzed various wound characteristics, characteristics of hospitalizations, the surgical or medical interventions received by patients, and laboratory parameters including CRP levels, total blood count, culture results, HbA1c levels, duration of diabetes, treatment received for diabetes, and antibiotic therapy regimens.
The percentage of patients who experienced side effects was as low as 6%, and none of them were critical. The most common side effect was discomfort due to the confined space in the chamber.
Appropriate patient selection, combined with a multidisciplinary approach to evaluate eligibility, is crucial to avoid adverse side effects. Patient education and early screening for side effects are also essential. Since various treatment protocols exist for HBO therapy, pooled data from different protocols may be misleading. Further studies focused on side effects with specific indications are necessary.
本研究旨在评估高压氧治疗相关的副作用，并为预防糖尿病足溃疡患者出现这些副作用提供建议。
高压氧治疗在糖尿病足溃疡治疗中的应用仍是一个有争议的问题，将副作用降至最低至关重要。虽然与高压氧（HBO）治疗相关的副作用发生率较低，但以多方面和跨学科的方式评估病例以预防不良后果至关重要。
在2018年至2020年期间进行了一项回顾性队列研究，涉及100例患者的数据集。该研究的主要目的是检查接受高压氧治疗（HBO）的糖尿病足溃疡（DFU）患者经历的副作用的频率和类型。此外，我们分析了各种伤口特征、住院特征、患者接受的手术或医疗干预，以及实验室参数，包括CRP水平、全血细胞计数、培养结果、糖化血红蛋白水平、糖尿病病程、糖尿病治疗情况和抗生素治疗方案。
出现副作用的患者比例低至6%，且均不严重。最常见的副作用是由于舱内空间狭小引起的不适。
适当的患者选择，结合多学科方法评估适用性，对于避免不良副作用至关重要。患者教育和早期副作用筛查也必不可少。由于存在多种HBO治疗方案，来自不同方案的汇总数据可能会产生误导。有必要开展针对特定适应症副作用的进一步研究。
