Tripathi Devika, Srivastava Mansi, Rathour Krislay, Rai Awani Kumar, Wal Pranay, Sahoo Jagannath, Tiwari Ritesh Kumar, Pandey Prashant
Pranveer Singh Institute of Technology (Pharmacy), Kanpur, India.
School of Pharmaceutical and Population Health Informatics, DIT University, Dehradun, India.
Drug Metab Bioanal Lett. 2023;16(2):89-104. doi: 10.2174/2949681016666230803150329.
Psoriasis is a complex autoimmune skin condition with a significant genetic component. It causes skin inflammation and is characterized by flaky, silvery reddish spots that can worsen with age. This condition results from an impaired immunological response of T-cells and affects 2-5% of the global population. The severity of the illness determines the choice of treatment. Topical treatments are commonly used to treat psoriasis, but they can have several adverse effects. Biological therapy is another option for treating specific types of psoriasis. Recently, new nanoformulations have revolutionized psoriasis treatment. Various nanocarriers, such as liposomes, nanostructured lipid nanoparticles, niosomes, and nanoemulsions, have been developed and improved for drug delivery. The use of nanocarriers enhances patient compliance, precise drug delivery, and drug safety. This review aims to suggest new nanocarrier-based drug delivery systems for treating psoriasis. It discusses the importance of nanocarriers and compares them to traditional treatments. Anti-psoriatic drugs have also been investigated for cutaneous delivery using nanocarriers. The review also covers various factors that influence dermal targeting. By highlighting several relevant aspects of psoriasis treatment, the review emphasizes the current potential of nanotechnology. Using nanocarriers as a drug delivery technique may be a promising alternative treatment for psoriasis.
银屑病是一种具有重要遗传成分的复杂自身免疫性皮肤病。它会引发皮肤炎症，其特征是出现片状、银红色斑点，且可能随年龄增长而恶化。这种病症是由T细胞免疫反应受损导致的，全球约2% - 5%的人口受其影响。病情的严重程度决定治疗方法的选择。局部治疗是治疗银屑病常用的方法，但可能会有多种不良反应。生物疗法是治疗特定类型银屑病的另一种选择。最近，新型纳米制剂彻底改变了银屑病的治疗方式。已开发并改进了各种纳米载体，如脂质体、纳米结构脂质纳米粒、非离子表面活性剂囊泡和纳米乳剂用于药物递送。纳米载体的使用提高了患者的依从性、实现了精确的药物递送并提升了药物安全性。本综述旨在提出用于治疗银屑病的新型基于纳米载体的药物递送系统。它讨论了纳米载体的重要性，并将其与传统治疗方法进行比较。还研究了使用纳米载体进行皮肤给药的抗银屑病药物。该综述还涵盖了影响皮肤靶向的各种因素。通过强调银屑病治疗的几个相关方面，本综述强调了纳米技术目前的潜力。使用纳米载体作为药物递送技术可能是银屑病一种有前景的替代治疗方法。
