2010 年至 2019 年，间充质干细胞治疗悬韧带分支撕裂的纯种赛马的赛马表现。

Racing performance of Thoroughbred racehorses with suspensory ligament branch desmitis treated with mesenchymal stem cells (2010-2019).

机构信息

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.

Rood and Riddle Equine Hospital, Lexington, Kentucky, USA.

出版信息

Equine Vet J. 2024 May;56(3):503-513. doi: 10.1111/evj.13980. Epub 2023 Aug 3.

DOI:10.1111/evj.13980

PMID:37534804

Abstract

BACKGROUND

Suspensory ligament branch desmitis (SLBD) is a common injury in Thoroughbred racehorses. Orthobiologic treatment of these injuries is a relatively new approach, and there is limited information available on post injury racing performance in racehorses treated with mesenchymal stem cells (MSCs).

OBJECTIVES

To assess racing performance post injury in Thoroughbred racehorses with SLBD treated with MSCs.

STUDY DESIGN

Retrospective case series.

METHODS

Medical records of racehorses with SLBD treated with MSCs from 2010 to 2019 were reviewed. All horses were treated with allogeneic stem cells injected locally at the time of diagnosis and subsequently received 3-4 treatments with autologous bone-marrow derived MSCs. Ultrasonographic and radiographic images were evaluated to determine the degree of suspensory branch injury and sesamoiditis of the associated proximal sesamoid bone. Race performance was assessed by career length, class of races, number of starts and earnings post injury. Race performance of horses that raced pre and post injury were compared.

RESULTS

Of 69 treated horses, 71% (49/69) [95% CI: 59%-81%] raced post injury. Horses that had raced pre injury were more likely to race post injury (90% [18/20]) than horses that did not race pre injury (63% [31/49]; p = 0.03). Females were less likely to race post injury than males (52% [11/21] vs. 79% [38/49], respectively; p = 0.02). In the 18 horses that raced pre and post injury, the number of races, earnings and earnings per start were not significantly different pre and post injury. The average career length of all horses that raced post injury was 29.5 months.

MAIN LIMITATIONS

Retrospective study design and lack of controls.

CONCLUSIONS

Treatment with MSCs resulted in a majority of Thoroughbred racehorses with SLBD racing post treatment. Racing pre injury and being male was positively associated with racing post injury.

摘要

背景

悬韧带分支撕裂（SLBD）是纯种赛马中常见的损伤。这些损伤的矫形生物治疗是一种相对较新的方法，关于用间充质干细胞（MSCs）治疗后赛马的赛后比赛表现，信息有限。

目的

评估 SLBD 用 MSCs 治疗的纯种赛马赛后比赛表现。

研究设计

回顾性病例系列。

方法

回顾了 2010 年至 2019 年用 MSCs 治疗 SLBD 的赛马的医疗记录。所有马在诊断时均接受同种异体干细胞局部注射治疗，随后接受 3-4 次自体骨髓衍生 MSCs 治疗。评估超声和放射图像以确定悬韧带分支损伤和相关近端籽骨的籽骨炎的程度。通过职业生涯长度、比赛级别、赛后起跑次数和收入来评估比赛表现。比较受伤前后参赛的马匹的比赛表现。

结果

在 69 匹接受治疗的马中，71%（49/69）[95%CI：59%-81%]在受伤后参赛。受伤前参赛的马比未参赛的马（90%[18/20]比 63%[31/49]；p=0.03）更有可能在受伤后参赛。雌性比雄性更不可能在受伤后参赛（52%[11/21]比 79%[38/49]；p=0.02）。在 18 匹受伤前后参赛的马中，赛前和赛后的比赛次数、收入和每场比赛的收入没有显著差异。所有参赛马的平均职业生涯长度为 29.5 个月。