心血管健康与认知结局：来自美国一项两民族人群为基础的研究结果。
Cardiovascular health and cognitive outcomes: Findings from a biracial population-based study in the United States.
机构信息
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.
出版信息
Alzheimers Dement. 2023 Oct;19(10):4446-4453. doi: 10.1002/alz.13421. Epub 2023 Aug 3.
INTRODUCTION
The aim of this study was to evaluate the association of cardiovascular health (CVH) with cognitive outcomes, including incident Alzheimer's dementia, rate of cognitive decline, and measures of brain injury and structure.
METHODS
This study consisted of 1702 Black or African American and White participants living in the south side of Chicago, Illinois, and enrolled in the Chicago Health and Aging Project, a population-based cohort since 1993. CVH was based on seven risk factors, including diet, physical activity, body mass index, smoking, dyslipidemia, hypertension, and diabetes.
RESULTS
In a multivariable-adjusted model, CVH was associated with a lower risk of Alzheimer's dementia. The hazard ratio per 1 additional point in CVH score was 0.84 (95% CI 0.76, 0.94). CVH was also associated with a slower rate of cognitive decline and less volume (injury) in white matter hyperintensities.
DISCUSSION
Promoting CVH in communities with Black residents may lower the future risk of Alzheimer's dementia.
简介
本研究旨在评估心血管健康 (CVH) 与认知结果的关联，包括阿尔茨海默病痴呆的发病情况、认知下降的速度，以及脑损伤和结构的测量。
方法
本研究包括居住在伊利诺伊州芝加哥南部并参加自 1993 年以来开展的基于人群的芝加哥健康与衰老项目的 1702 名黑人和非裔美国人及白人参与者。CVH 基于 7 种风险因素，包括饮食、身体活动、体重指数、吸烟、血脂异常、高血压和糖尿病。
结果
在多变量调整模型中，CVH 与阿尔茨海默病痴呆的风险降低相关。CVH 评分每增加 1 分，风险比为 0.84（95%CI 0.76，0.94）。CVH 还与认知下降速度较慢以及脑白质高信号体积（损伤）较小相关。
讨论
在有黑人居民的社区促进 CVH 可能会降低未来患阿尔茨海默病的风险。
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