非裔美国人和欧裔美国人的遗传风险、健康生活方式的坚持与认知能力下降。
Genetic risk, adherence to a healthy lifestyle, and cognitive decline in African Americans and European Americans.
机构信息
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.
出版信息
Alzheimers Dement. 2022 Apr;18(4):572-580. doi: 10.1002/alz.12435. Epub 2021 Jul 26.
INTRODUCTION
We investigated the role of genetic risk and adherence to lifestyle factors on cognitive decline in African Americans and European Americans.
METHODS
Using data from the Chicago Health and Aging Project (1993-2012; n = 3874), we defined the genetic risk based on presence of apolipoprotein E (APOE) allele and determined a healthy lifestyle using a scoring of five factors: non-smoking, exercising, being cognitively active, having a high-quality diet, and limiting alcohol use. We used linear mixed-effects models to estimate cognitive decline by genetic risk and lifestyle score.
RESULTS
APOE allele was associated with faster cognitive decline in both races. However, within APOE carriers, adherence to a healthy lifestyle (eg., 4 to 5 healthy factors) was associated with a slower cognitive decline by 0.023 (95% confidence interval [CI] 0.004, 0.042) units/year in African Americans and 0.044 (95% CI 0.008, 0.080) units/year in European Americans.
DISCUSSION
A healthy lifestyle was associated with a slower cognitive decline in African and European Americans.
简介
我们研究了遗传风险和生活方式因素的依从性对非裔美国人和欧洲裔美国人认知能力下降的作用。
方法
利用来自芝加哥健康与老龄化项目（1993-2012 年；n=3874）的数据，我们根据载脂蛋白 E（APOE）等位基因的存在定义遗传风险，并使用五个因素的评分来确定健康的生活方式：不吸烟、锻炼、保持认知活跃、拥有高质量饮食和限制饮酒。我们使用线性混合效应模型来估计遗传风险和生活方式评分对认知能力下降的影响。
结果
APOE等位基因与两种族的认知能力下降均有关。然而，在 APOE携带者中，坚持健康的生活方式（例如，有 4 到 5 个健康因素）与认知能力下降的速度较慢有关，每年下降 0.023 个单位（95%置信区间 0.004，0.042）在非裔美国人和每年下降 0.044 个单位（95%置信区间 0.008，0.080）在欧洲裔美国人中。
讨论
健康的生活方式与非裔美国人和欧洲裔美国人认知能力下降速度较慢有关。
Zotero 插件