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Inhibin A-subunit gene expression in the ovaries of immature female rats is stimulated by pregnant mare serum gonadotrophin.

作者信息

Davis S R, Dench F, Nikolaidis I, Clements J A, Forage R G, Krozowski Z, Burger H G

出版信息

Biochem Biophys Res Commun. 1986 Aug 14;138(3):1191-5. doi: 10.1016/s0006-291x(86)80408-9.

DOI:10.1016/s0006-291x(86)80408-9
PMID:3753494
Abstract

We have used a bovine cDNA probe for the A-subunit of inhibin to demonstrate the presence of inhibin in the ovaries of immature female rats: the levels of mRNA were increased following treatment of the rats with pregnant mare serum gonadotrophin (PMSG), suggesting modulation by PMSG of ovarian inhibin synthesis at least at the level of transcription. Furthermore, we report the unexpected finding of significant levels of inhibin mRNA in the corpora lutea of mature female rats. No inhibin mRNA was demonstrable in the uterus or placenta.

摘要

相似文献

1
Inhibin A-subunit gene expression in the ovaries of immature female rats is stimulated by pregnant mare serum gonadotrophin.
Biochem Biophys Res Commun. 1986 Aug 14;138(3):1191-5. doi: 10.1016/s0006-291x(86)80408-9.
2
Human chorionic gonadotrophin-induced suppression of serum inhibin involves reduction in ovarian inhibin alpha-subunit messenger RNA levels in the pregnant mare serum gonadotrophin-primed female rat.人绒毛膜促性腺激素诱导的血清抑制素抑制作用涉及孕马血清促性腺激素预处理的雌性大鼠卵巢抑制素α亚基信使核糖核酸水平的降低。
Mol Cell Endocrinol. 1989 Jan;61(1):123-8. doi: 10.1016/0303-7207(89)90196-2.
3
Pregnant mare's serum gonadotropin stimulates inhibin subunit gene expression in the immature rat ovary: dose response characteristics and relationships to serum gonadotropins, inhibin, and ovarian steroid content.
Endocrinology. 1988 Nov;123(5):2399-407. doi: 10.1210/endo-123-5-2399.
4
The biphasic modulation of inhibin mRNA levels and secretion by PMSG in rat granulosa cells in vitro.
Reprod Fertil Dev. 1991;3(2):215-26. doi: 10.1071/rd9910215.
5
Indomethacin inhibits the secretion of inhibin and oestradiol-17 beta stimulated by pregnant mare serum gonadotrophin in the immature female rat.
Eur J Pharmacol. 1992 Oct 20;221(2-3):289-95. doi: 10.1016/0014-2999(92)90715-g.
6
In vivo hormonal regulation of insulin-like growth factor binding protein-5 mRNA in the immature rat ovary.未成熟大鼠卵巢中胰岛素样生长因子结合蛋白-5 mRNA的体内激素调节
J Soc Gynecol Investig. 1995 Nov-Dec;2(6):735-42.
7
Inhibin mRNAs in ovine and bovine ovarian follicles and corpora lutea throughout the estrous cycle and gestation.整个发情周期和妊娠期绵羊和牛卵巢卵泡及黄体中的抑制素信使核糖核酸
Mol Cell Endocrinol. 1989 Mar;62(1):95-101. doi: 10.1016/0303-7207(89)90117-2.
8
Inhibin subunit gene expression and distribution in the ovaries of immature, young adult, middle-aged, and old female rats.抑制素亚基基因在未成熟、年轻成年、中年和老年雌性大鼠卵巢中的表达及分布
Endocrinology. 1993 Jan;132(1):319-26. doi: 10.1210/endo.132.1.8419130.
9
Baseline and stimulated serum inhibin levels as biomarkers of cisplatin-induced ovarian damage in female rats.基线和刺激后的血清抑制素水平作为雌性大鼠顺铂诱导的卵巢损伤生物标志物
Am J Obstet Gynecol. 2008 Jan;198(1):82.e1-6. doi: 10.1016/j.ajog.2007.06.001.
10
Ovarian and peripheral blood inhibin concentrations increase with gonadotropin treatment in immature rats.在未成熟大鼠中，促性腺激素治疗后卵巢和外周血抑制素浓度升高。
Endocrinology. 1981 Jun;108(6):2403-5. doi: 10.1210/endo-108-6-2403.

引用本文的文献

1
Gonadotropic control of secretion of dimeric inhibins and activin A by human granulosa-luteal cells in vitro.人颗粒黄体细胞体外分泌二聚体抑制素和激活素A的促性腺激素调控
J Assist Reprod Genet. 1997 Nov;14(10):566-74. doi: 10.1023/a:1022524516824.
2
Human chorionic gonadotropin inhibits proliferation and induces expression of inhibin in human breast epithelial cells in vitro.人绒毛膜促性腺激素在体外抑制人乳腺上皮细胞增殖并诱导抑制素表达。
In Vitro Cell Dev Biol Anim. 1994 Jan;30A(1):4-8. doi: 10.1007/BF02631407.
3
Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions.
抑制素α、βA和βB亚基在各种组织中的性腺和性腺外表达预示着多种功能。
Proc Natl Acad Sci U S A. 1988 Jan;85(1):247-51. doi: 10.1073/pnas.85.1.247.
4
Recent advances in the human physiology of inhibin secretion.抑制素分泌的人体生理学最新进展。
J Endocrinol Invest. 1990 Jul-Aug;13(7):611-24. doi: 10.1007/BF03348643.
5
Activin-A as an intraovarian modulator: actions, localization, and regulation of the intact dimer in human ovarian cells.激活素A作为卵巢内调节剂：在人卵巢细胞中的作用、定位及完整二聚体的调节
J Clin Invest. 1992 May;89(5):1528-36. doi: 10.1172/JCI115745.