Li Xiaojie, Xie Jinying, Xu Jiahong, Deng Langjing, Cao Ganxiang, Huang Songyi, Zeng Chenyan, Liu Chaoqun, Zhu Sui, He Guanhao, Lin Ziqiang, Ma Wenjun, Yang Pan, Liu Tao
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China.
China Greater Bay Area Research Center of Environmental Health, School of Medicine, Jinan University, Guangzhou 510632, China.
Environ Sci Technol. 2023 Aug 15;57(32):11792-11802. doi: 10.1021/acs.est.3c02646. Epub 2023 Aug 3.
Cataract is one key cause of visual disability and blindness. Ambient particulate matter is more likely to increase cataract risk due to eye continuous exposure to the environment. However, less is known about whether long-term exposure to particulate matter 2.5 (PM) is related to age-related cataracts. We conducted a population-based study among 22,298 adults from two multicenter cohort studies [China Family Panel Studies (CFPS) and Chinese Longitudinal Healthy Longevity Survey (CLHLS)]. The associations between PM and age-related cataracts were analyzed by Cox proportional hazard regression models, which were also stratified according to demographic characteristics. The restricted cubic spline (RCS) model was used to explore the dose-response relationships between PM and age-related cataracts. The population attributable fraction (PAF) was calculated to assess the burden of age-related cataracts that can be attributed to PM. In the final analysis, 1897 participants reported age-related cataracts during follow-up. Long-term exposure to PM was associated with age-related cataracts, with HRs of 1.165 (1.130, 1.201), 1.138 (1.103, 1.173), and 1.091 (1.057, 1.126) for per 10 μg/m increase at one-, two-, and three-year before the end of follow-up, respectively. Furthermore, associations between PM and age-related cataracts were also demonstrated in RCS models. The PAF of age-related cataracts to PM in the total participants was 24.63%. Our research found that long-term exposure to PM may increase the risk of age-related cataracts, and age-related cataracts should be considered as an important public health issue due to air pollution.
白内障是导致视力残疾和失明的一个关键原因。由于眼睛持续暴露于环境中，环境颗粒物更有可能增加患白内障的风险。然而，关于长期暴露于细颗粒物2.5（PM2.5）是否与年龄相关性白内障有关，人们所知甚少。我们在来自两项多中心队列研究[中国家庭追踪调查（CFPS）和中国老年健康影响因素跟踪调查（CLHLS）]的22298名成年人中开展了一项基于人群的研究。通过Cox比例风险回归模型分析PM2.5与年龄相关性白内障之间的关联，并根据人口统计学特征进行分层。采用受限立方样条（RCS）模型探索PM2.5与年龄相关性白内障之间的剂量反应关系。计算人群归因分数（PAF）以评估可归因于PM2.5的年龄相关性白内障负担。在最终分析中，1897名参与者在随访期间报告患有年龄相关性白内障。长期暴露于PM2.5与年龄相关性白内障有关，在随访结束前1年、2年和3年，每增加10μg/m³的HR分别为1.165（1.130，1.201）、1.138（1.103，1.173）和1.091（1.057，1.126）。此外，RCS模型也显示了PM2.5与年龄相关性白内障之间的关联。在所有参与者中，年龄相关性白内障对PM2.5的PAF为24.63%。我们的研究发现，长期暴露于PM2.5可能会增加年龄相关性白内障的风险，并且由于空气污染，年龄相关性白内障应被视为一个重要的公共卫生问题。
