Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Cancer Research Institute of Hengyang Medical School, University of South China, 28 Changsheng Road, Hengyang, 421001, Hunan Province, People's Republic of China.
Department of Pathology, People's Hospital of Shaoyang County, Hengyang, Hunan Province, People's Republic of China.
Cancer Chemother Pharmacol. 2023 Nov;92(5):329-340. doi: 10.1007/s00280-023-04572-1. Epub 2023 Aug 3.
Gastric cancer (GC) is a common malignant tumor with high morbidity and mortality rates that seriously affects human health worldwide. Although surgery is currently the preferred clinical treatment for GC, chemotherapy remains the first choice for perioperative treatment, adjuvant therapy, and palliative care for patients with advanced GC. Cisplatin (DDP) is an antineoplastic agent that has been used clinically for decades, and it is the first-line chemotherapy for many solid tumors. However, the therapeutic efficacy of DDP is often limited by resistance and the complexity of its resistance mechanisms, which involve multiple proteins and signaling pathways. It is well documented that a variety of microRNAs (miRNAs) differentially expressed in DDP-resistant GC cells play important roles in regulating or reversing DDP resistance via various pathways. In this review, we first provide an introduction to the cytotoxicity and major resistance mechanisms of DDP in GC and then discuss the role and mechanism of miRNAs in regulating the DDP resistance process in GC cells. This work demonstrates the potential of relevant miRNAs to become diagnostic and prognostic biomarkers for gastric cancer and targets of action to enhance chemosensitivity and provides directions for future research.
胃癌（GC）是一种常见的恶性肿瘤，发病率和死亡率都很高，严重影响着全球人类的健康。尽管手术目前是 GC 的首选临床治疗方法，但化疗仍然是 GC 围手术期治疗、辅助治疗和晚期 GC 姑息治疗的首选。顺铂（DDP）是一种抗癌药物，已在临床上使用了几十年，是许多实体瘤的一线化疗药物。然而，DDP 的治疗效果往往受到耐药性的限制，其耐药机制复杂，涉及多种蛋白质和信号通路。有大量文献报道，DDP 耐药 GC 细胞中差异表达的多种 microRNAs（miRNAs）通过多种途径在调节或逆转 DDP 耐药中发挥重要作用。在本综述中，我们首先介绍了 DDP 在 GC 中的细胞毒性和主要耐药机制，然后讨论了 miRNAs 在调节 GC 细胞中 DDP 耐药过程中的作用和机制。这项工作证明了相关 miRNAs 作为胃癌诊断和预后生物标志物以及增强化疗敏感性的作用靶点的潜力，并为未来的研究提供了方向。
