Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
DNA Cell Biol. 2023 Aug;42(8):445-455. doi: 10.1089/dna.2023.0071. Epub 2023 Aug 3.
In the tumor microenvironment, tumor-associated macrophages (TAMs) are one of the most abundant cell populations, playing key roles in tumorigenesis, chemoresistance, immune evasion, and metastasis. There is an important interaction between TAMs and cancer cells: on the one hand, tumors control the function of infiltrating macrophages, contributing to reprogramming of TAMs, and on the other hand, TAMs affect the growth of cancer cells. This review focuses on lipid metabolism changes in the complex relationship between cancer cells and TAMs. We discuss how lipid metabolism in cancer cells affects macrophage phenotypic and metabolic changes and, subsequently, how altered lipid metabolism of TAMs influences tumor progression. Identifying the metabolic changes that influence the complex interaction between tumor cells and TAMs is also an important step in exploring new therapeutic approaches that target metabolic reprogramming of immune cells to enhance their tumoricidal potential and bypass therapy resistance. Our work may provide new targets for antitumor therapies.
在肿瘤微环境中，肿瘤相关巨噬细胞（TAMs）是最丰富的细胞群体之一，在肿瘤发生、化疗耐药、免疫逃逸和转移中发挥关键作用。TAMs 与癌细胞之间存在重要的相互作用：一方面，肿瘤控制浸润巨噬细胞的功能，有助于 TAMs 的重编程，另一方面，TAMs 影响癌细胞的生长。本综述重点关注癌细胞和 TAMs 之间复杂关系中的脂质代谢变化。我们讨论了癌细胞中的脂质代谢如何影响巨噬细胞表型和代谢变化，以及随后 TAMs 改变的脂质代谢如何影响肿瘤进展。鉴定影响肿瘤细胞和 TAMs 之间复杂相互作用的代谢变化也是探索靶向免疫细胞代谢重编程以增强其杀瘤潜力和绕过治疗耐药性的新治疗方法的重要步骤。我们的工作可能为抗肿瘤治疗提供新的靶点。
