Department of Radiation Oncology, Peking University Third Hospital, Beijing, China
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
J Immunother Cancer. 2021 Jan;9(1). doi: 10.1136/jitc-2020-001341.
Macrophages are the most important phagocytes in vivo. However, the tumor microenvironment can affect the function and polarization of macrophages and form tumor-associated macrophages (TAMs). Usually, the abundance of TAMs in tumors is closely associated with poor prognosis. Preclinical studies have identified important pathways regulating the infiltration and polarization of TAMs during tumor progression. Furthermore, potential therapeutic strategies targeting TAMs in tumors have been studied, including inhibition of macrophage recruitment to tumors, functional repolarization of TAMs toward an antitumor phenotype, and other therapeutic strategies that elicit macrophage-mediated extracellular phagocytosis and intracellular destruction of cancer cells. Therefore, with the increasing impact of tumor immunotherapy, new antitumor strategies to target TAMs are now being discussed.
巨噬细胞是体内最重要的吞噬细胞。然而，肿瘤微环境可以影响巨噬细胞的功能和极化，形成肿瘤相关巨噬细胞（TAMs）。通常，肿瘤中 TAMs 的丰度与预后不良密切相关。临床前研究已经确定了调节肿瘤进展过程中 TAMs 浸润和极化的重要途径。此外，还研究了针对肿瘤中 TAMs 的潜在治疗策略，包括抑制巨噬细胞向肿瘤的募集、将 TAMs 的功能重新极化为抗肿瘤表型，以及其他引发巨噬细胞介导的细胞外吞噬和细胞内破坏癌细胞的治疗策略。因此，随着肿瘤免疫治疗的影响不断增加，现在正在讨论针对 TAMs 的新的抗肿瘤策略。
