年龄、性别、饮酒及吸烟对津巴布韦黑人血脂和载脂蛋白血清浓度的影响。
The effect of age, sex, alcohol consumption and cigarette smoking on serum concentrations of lipids and apolipoproteins in Zimbabwean blacks.
作者信息
Gomo Z A
出版信息
Atherosclerosis. 1986 Aug;61(2):149-54. doi: 10.1016/0021-9150(86)90075-4.
Serum concentrations of total cholesterol, HDL cholesterol, triglycerides and apolipoproteins A-I and B were studied in black subjects with no known risk factor for coronary heart disease and in subjects with a single risk factor. The concentrations of lipids and apolipoproteins were sex-dependent. HDL cholesterol and apolipoprotein A-I were age-dependent in females (P less than 0.05 and P less than 0.01, respectively). There was a dose-related association between alcohol consumption and serum concentrations of triglycerides, HDL cholesterol, apolipoproteins A-I and B in males (P less than 0.001 and P less than 0.002, respectively in the heavy drinkers). The effects of cigarette smoking on the concentrations of serum lipids and apolipoproteins appear to be prominent in the heavy smoking subjects (P less than 0.001 and P less than 0.001, respectively). This work suggests that HDL cholesterol and apolipoprotein A-I may discriminate black subjects at risk of developing atherosclerosis.
在无已知冠心病危险因素的黑人受试者以及有单一危险因素的受试者中，研究了血清总胆固醇、高密度脂蛋白胆固醇、甘油三酯以及载脂蛋白A-I和B的浓度。脂质和载脂蛋白的浓度存在性别差异。在女性中，高密度脂蛋白胆固醇和载脂蛋白A-I与年龄有关（分别为P<0.05和P<0.01）。男性中，饮酒量与甘油三酯、高密度脂蛋白胆固醇、载脂蛋白A-I和B的血清浓度之间存在剂量相关关联（重度饮酒者中分别为P<0.001和P<0.002）。重度吸烟受试者中，吸烟对血清脂质和载脂蛋白浓度的影响似乎较为显著（分别为P<0.001和P<0.001）。这项研究表明，高密度脂蛋白胆固醇和载脂蛋白A-I可能有助于鉴别有发生动脉粥样硬化风险的黑人受试者。
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