State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao Special Administrative Region of China.
State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Biomed Pharmacother. 2023 Sep;165:115198. doi: 10.1016/j.biopha.2023.115198. Epub 2023 Aug 1.
Systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune system attacks its own tissues and organs. However, the causes of SLE remain unknown. Dyslipidemia is a common symptom observed in SLE patients and animal models and is closely correlated to disease activity. Lipid metabolic reprogramming has been considered as a hallmark of the dysfunction of T cells in patients with SLE, therefore, manipulating lipid metabolism provides a potential therapeutic target for treating SLE. A better understanding of the underlying mechanisms for the metabolic events of immune cells under pathological conditions is crucial for tuning immunometabolism to manage autoimmune diseases such as SLE. In this review, we aim to summarize the cross-link between lipid metabolism and the function of T cells as well as the underlying mechanisms, and provide light on the novel therapeutic strategies of active compounds from herbals for the treatment of SLE by targeting lipid metabolism in immune cells.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，其中免疫系统攻击自身的组织和器官。然而，SLE 的病因仍不清楚。血脂异常是 SLE 患者和动物模型中常见的症状，与疾病活动密切相关。脂质代谢重编程被认为是 SLE 患者 T 细胞功能障碍的标志，因此，操纵脂质代谢为治疗 SLE 提供了一个潜在的治疗靶点。更好地了解免疫细胞在病理条件下代谢事件的潜在机制对于调节免疫代谢以治疗自身免疫性疾病（如 SLE）至关重要。在这篇综述中，我们旨在总结脂质代谢与 T 细胞功能之间的交叉联系以及潜在的机制，并提供有关通过靶向免疫细胞中的脂质代谢来治疗 SLE 的草药中活性化合物的新型治疗策略的启示。
