Department of Rheumatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Department of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Southeast University, Nanjing, China.
Front Immunol. 2022 Mar 18;13:860586. doi: 10.3389/fimmu.2022.860586. eCollection 2022.
Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized by the production of abnormal autoantibodies and immune complexes that can affect the organ and organ systems, particularly the kidneys and the cardiovascular system. Emerging evidence suggests that dysregulated lipid metabolism, especially in key effector cells, such as T cells, B cells, and innate immune cells, exerts complex effects on the pathogenesis and progression of SLE. Beyond their important roles as membrane components and energy storage, different lipids can also modulate different cellular processes, such as proliferation, differentiation, and survival. In this review, we summarize altered lipid metabolism and the associated mechanisms involved in the pathogenesis and progression of SLE. Furthermore, we discuss the recent progress in the role of lipid metabolism as a potential therapeutic target in SLE.
系统性红斑狼疮（SLE）是一种异质性疾病，其特征是产生异常的自身抗体和免疫复合物，可影响器官和器官系统，特别是肾脏和心血管系统。新出现的证据表明，脂质代谢失调，特别是在关键效应细胞中，如 T 细胞、B 细胞和固有免疫细胞，对 SLE 的发病机制和进展产生复杂的影响。除了作为膜成分和能量储存的重要作用外，不同的脂质还可以调节不同的细胞过程，如增殖、分化和存活。在这篇综述中，我们总结了改变的脂质代谢以及与 SLE 的发病机制和进展相关的机制。此外，我们还讨论了脂质代谢作为 SLE 潜在治疗靶点的最新进展。
