Department of Neurology and Institute of Neuroimmunology, Tianjin Medical University General Hospital, Tianjin, China.
Department of Neurology and Institute of Neuroimmunology, Tianjin Medical University General Hospital, Tianjin, China; Center of Neuroimmunology and Neurological Diseases, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
J Neuroimmunol. 2023 Sep 15;382:578167. doi: 10.1016/j.jneuroim.2023.578167. Epub 2023 Jul 29.
Autoreactive CD4 helper T cells are implicated in the pathogenesis of neuromyelitis optica spectrum disorder (NMOSD). Both PD-1CXCR5CD4 T follicular helper (Tfh) cells and PD-1CXCR5CD4 T peripheral helper (Tph) cells can contribute to B-cell immune responses and the production of antibodies. Here we show the effect of B-cell depletion with rituximab on the homeostasis of Tfh cells, Tph cells and their subsets in patients with NMOSD. After rituximab treatment, total Tph cells, total Tfh cells, Tph17 cells, Tph17.1 cells, Tph1 cells, and Tfh1 cells tended to decrease at month 1, but gradually increased at month 6 and restored at month 12. Besides, Tph17.1 cells and Tfh17.1 cells were correlated with the proportion of CD19 antibody-secreting cells. Our data suggest that rituximab induced a fluctuation of proinflammatory Tph and Tfh subsets within one year after initiation of the treatment.
自身反应性 CD4 辅助 T 细胞被认为与视神经脊髓炎谱系障碍（NMOSD）的发病机制有关。PD-1CXCR5CD4 滤泡辅助 T（Tfh）细胞和 PD-1CXCR5CD4 外周辅助 T（Tph）细胞都可以促进 B 细胞免疫反应和抗体产生。在这里，我们展示了利妥昔单抗对 NMOSD 患者 Tfh 细胞、Tph 细胞及其亚群的稳态的影响。利妥昔单抗治疗后，总 Tph 细胞、总 Tfh 细胞、Tph17 细胞、Tph17.1 细胞、Tph1 细胞和 Tfh1 细胞在第 1 个月趋于下降，但在第 6 个月逐渐增加，并在第 12 个月恢复。此外，Tph17.1 细胞和 Tfh17.1 细胞与 CD19 抗体分泌细胞的比例相关。我们的数据表明，利妥昔单抗诱导了治疗开始后一年内促炎 Tph 和 Tfh 亚群的波动。
