Dai Jie, Zhang Min-Zhe, He Qi-Qiang, Chen Rui
School of Public Health, Wuhan University, Wuhan, China.
School of Public Health, Wuhan University, Wuhan, China; Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, China.
Psychiatry Res. 2023 Sep;327:115394. doi: 10.1016/j.psychres.2023.115394. Epub 2023 Jul 30.
Schizophrenia (SCZ), a serious mental disorder, is one of the leading causes of disease burden worldwide. Exosomes, as a natural nanocarrier, are able to cross the blood-brain barrier (BBB) and play a key bridging role in central nervous system (CNS) communication, participating in important physiological processes such as neural regeneration, prominent plasticity, axonal support, and neuroinflammation. In recent years, exosomes have received widespread attention in the field of neurodegenerative diseases and mental disorders, especially Alzheimer's disease. However, there are few reviews on exosomes and SCZ. Therefore, we conducted a literature search in PubMed and Web of Science using the following search terms: "schizophrenia", "mental disorder", "central system", "exosome", "extracellular vesicles" to identify publications from January 2010 to December 2022. Our review summarized exosomes secreted by different cell types in the CNS and the double-edged role of exosomes in the development of SCZ, and discussed their future potential as biomarkers and therapeutic targets. In conclusion, this article provides an up-to-date overview of the current research on the involvement of exosomes in SCZ, while also highlighting the challenges that are currently faced in this field.
精神分裂症（SCZ）是一种严重的精神障碍，是全球疾病负担的主要原因之一。外泌体作为一种天然纳米载体，能够穿过血脑屏障（BBB），在中枢神经系统（CNS）通讯中发挥关键的桥梁作用，参与神经再生、显著可塑性、轴突支持和神经炎症等重要生理过程。近年来，外泌体在神经退行性疾病和精神障碍领域，尤其是阿尔茨海默病中受到了广泛关注。然而，关于外泌体与精神分裂症的综述较少。因此，我们在PubMed和Web of Science中使用以下检索词进行文献检索：“精神分裂症”、“精神障碍”、“中枢系统”、“外泌体”、“细胞外囊泡”，以识别2010年1月至2022年12月期间的出版物。我们的综述总结了中枢神经系统中不同细胞类型分泌的外泌体以及外泌体在精神分裂症发展中的双刃剑作用，并讨论了它们作为生物标志物和治疗靶点的未来潜力。总之，本文提供了外泌体参与精神分裂症研究的最新概述，同时也强调了该领域目前面临的挑战。
